The bongino report

New Onset Seizures After COVID-19 Vaccination

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Fan HT, Lin YY, Chiang WF, Lin CY, Chen MH, Wu KA, Chan JS, Kao YH, Shyu HY, Hsiao PJ. COVID-19 vaccine-induced encephalitis and status epilepticus. QJM. 2022 Feb 21;115(2):91-93. doi: 10.1093/qjmed/hcab335. PMID: 34978572; PMCID: PMC9383153.

Comprehensive testing including repeated spinal taps demonstrated indirect evidence of the Spike protein produced by the mRNA vaccine within the brain.  They found IgG directed against the receptor binding domain of the Spike protein in cerebral spinal fluid and over time, the concentrations of this antibody were discordant with serum levels, suggesting the Spike protein was indeed within the brain where it would be expected to cause inflammation and trigger a seizure.

Sriwastava and colleagues, from Department of Neurology, Rockefeller Neuroscience Institute, West Virginia University, in a review article, felt seizures were well within the realm of neurologic side effects from the COVID-19 vaccines. [ii]

Kaculini et al, from the University of Texas Health Science Center at San Antonio, wrote in a 2021 historical review [iii]:  “Epilepsy is an ancient disease, which has fascinated and frightened scientists and laymen alike. Before the working knowledge of the central nervous system, seizures were shrouded in mystery. In antiquity, this disease was accredited to gods and demonic possession, causing those with epilepsy to be feared and isolated. Epilepsy patients continued to face discrimination through the mid-20th century. This discrimination ranged from lack of access to health insurance, jobs, and marriage equality to forced sterilizations. Despite the strides that have been made, there are still many misconceptions globally regarding epilepsy. Studies show that patients with epilepsy in communities that understand the pathology and cause of seizures are generally more successful in social and educational environments.”

So, if someone in your circles has been diagnosed with epilepsy or new onset seizures in the past few years with no obvious source (head trauma, neurosurgery, radiation, meningitis, etc) ask if they took one of the COVID-19 vaccines.

Vaccination can be quickly ruled out if the answer is “no.”  However, if COVID-19 vaccination is in the medical record, consider this possible etiology for seizures and take appropriate action.

Emergency room physicians and neurologists should be alerted to COVID-19 vaccine induced seizures at initial presentation.  While the prognosis is unknown given the novelty of these genetic products, provided no more injections are taken, I would expect that seizures would be progressively less frequent, better controlled, and potentially resolve with enough time.

Let this be a lesson learned, genetic material loaded on lipid nanoparticles is a terrible concept for a vaccine since it will go everywhere in the body including the brain where there can be inflammatory injury, disability, and sadly in some victims–death.

[i] Fan HT, Lin YY, Chiang WF, Lin CY, Chen MH, Wu KA, Chan JS, Kao YH, Shyu HY, Hsiao PJ. COVID-19 vaccine-induced encephalitis and status epilepticus. QJM. 2022 Feb 21;115(2):91-93. doi: 10.1093/qjmed/hcab335. PMID: 34978572; PMCID: PMC9383153.

[ii] Sriwastava S, Sharma K, Khalid SH, Bhansali S, Shrestha AK, Elkhooly M, Srivastava S, Khan E, Jaiswal S, Wen S. COVID-19 Vaccination and Neurological Manifestations: A Review of Case Reports and Case Series. Brain Sci. 2022 Mar 18;12(3):407. doi: 10.3390/brainsci12030407. PMID: 35326363; PMCID: PMC8946610.

[iii] Kaculini CM, Tate-Looney AJ, Seifi A. The History of Epilepsy: From Ancient Mystery to Modern Misconception. Cureus. 2021 Mar 17;13(3):e13953. doi: 10.7759/cureus.13953. PMID: 33880289; PMCID: PMC8051941.


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