Gut Bacteria Are Linked to Colorectal Cancer, 3 Ways to Improve
Colorectal Cancer is the most common form of cancer. Studies are showing that this is true in a growing number of cases. gut bacteria Have a significant influence on the development colorectal cancer. How can we create a healthy gut microbiome in order to prevent colorectal carcinoma?
The Gut Bacteria is closely related to Colorectal Cancer
There are many risk factors that can affect colorectal cancer, including genetic and environmental. Although the genetic factor is only 12 to 35 percent of the risk, the environmental factors have a greater impact. Particularly, Western lifestyles and diets can have a significant impact on the gut microbiome. increase the risk of colorectal cancer. Colorectal Cancer is also linked to poor oral hygiene habits.
Patients with colorectal carcinoma have a different gut microbiome than healthy patients. One study found Patients with colorectal carcinoma had more stool and tumor samples than normal. Escherichia coli, Bacteroides fragilis, Streptococcus gallolyticus, Enterococcus fasciculus, Fusobacterium nucleatumAnd Porphyromonas.
One of them is Escherichia coliA variety of bacteria that many people recognize. Although most bacteria in this group are harmless, some are still potentially harmful to humans. American Journal of Clinical Investigation It should be noted that Escherichia coli Positively associated with colorectal Cancer, with approximately 60 percent detection rate for colorectal patients and approximately 20% for healthy individuals.
Many bacteria found in patients with colorectal and other cancers are also associated with oral commensal bacteria. Fusobacterium nucleatum Porrinomonas gingivalis. A large-scale study Study results showed that women who had low tooth count and severe periodontal diseases were at 48 percent higher risk for developing colorectal carcinoma.
Ying Chieh Tsai, a probiotics expert in Asia and a chair Professor at National Yang Ming Chiao Tung University pointed out that these studies used comparative approaches to examine the differences in gut microbiome between healthy patients and those with colorectal disease. The scientific community is still not sure how these bacteria impact colorectal carcinoma.
The most popular theory currently accepted is that these are “bad” Bacteria can disrupt the balance in the gut microbiome, releasing toxins that directly or indirectly damage cells. They can also cause chronic inflammation and intestinal permeability changes. These changes can affect the mucosal cells in the large intestine. The cumulative damage can cause abnormal cell proliferation and genotoxicity that can lead to colon cancer and adenomas.
The Butyrate Paradox – Promotes Gut Health, Causes Cancer
Another factor in the association between gut bacteria and colorectal cancer is the secretion of the bacterial metabolite butyrate These bacteria can cause cell aging and inflammation and promote tumorigenesis.
However, it is paradoxical that short-chain fatty acid produced by gut bacteria fermenting dietary fibre, especially, can be harmful. butyrateThey are known to balance the gut microbiota and maintain the mucosal membrane. They also regulate energy expenditure and the host immune response. Probiotics can be considered butyrate-producing bacteria.
Tsai stated that butyrate can be produced by all kinds of bacteria. Bad bacteria may also produce it, but only in a limited amount. The main cause of the bad bacteria’s harm is the toxins they create. Over the years, paradoxical butyrate effects have been debated. This is called the butyrate paradox.
There are many perspectives and findings regarding this topic.
Concentration of butyrate
Butyrate in the right concentration is good for the body. However, too much can be harmful. The problem is that we don’t know the exact cutoff value.
Stem cells
Stem cells can be renewed and differentiated; they can also proliferate into the exact same type of cells and can differentiate into cells with different functions.
The differentiation of stem cell cells is the key to intestinal growth. Butyrate inhibits stem-cell growth, but it promotes growth of normal cells that differentiate form stem cells. The stem cells can then be protected by normal cells.
Tsai said that although we do not know the cause of it, Tsai believes that we can still understand it. “the growth of stem cells is not necessarily good, as it may lead to the differentiation and growth of cancer cells.”
Gut health
Butyrate can cause severe intestinal ulceration. It is safe for those with mild intestinal ulcers, or people who are perfectly healthy. This view has become widely accepted over the years.
Butyrate is good or bad? Tsai believes that there are good things more than bad. However, it is important to reduce fiber intake if your intestinal tract is inflamed or ulcerated. Probiotics should be avoided by people who are suffering from poor gut health, or have recently had surgery. This is because fiber and probiotics increase the amount of butyrate.
He said that patients with colorectal and other forms of cancer should be aware of the timing of probiotics. Patients with colorectal cancer are more likely than others to suffer from an imbalanced gut microbiota. They should take probiotics. Probiotics should not be taken by patients right after surgery, or during chemotherapy. Patients can opt to take probiotics only after their acute phase has ended.
3 Ways to Prevent Colorectal Cancer with Gut Microbiome
Can reducing certain bad bacteria in your body reduce your risk of colorectal Cancer? Yuan-Yu Jeng is a former chief medical officer at Taipei Veterans General Hospital’s Department of Infectious Disease. She pointed out that the microbiota of our digestive tract is in dynamic balance with our bodies, and many microorganisms make up an intricate ecosystem. The body is in constant state of flux, so removing bad bacteria will not always result in a positive outcome.
It is also not a good idea to prevent certain types of bacteria from entering the body, mainly because most of these bacteria are part of the body’s natural system. Bad bacteria can still be found in the body and will grow in an unhealthy environment.
Jeng believes that maintaining the micro-ecosystem is the best solution. This includes maintaining a healthy diet and exercise, good mental well-being, good oral hygiene, and managing chronic diseases like the “three highs.”
However, modulating your gut microbiome is still an effective tool for colorectal and other forms of cancer prevention. This can be done in a number of ways:
1. Change your dietary habits
It takes time to improve your gut microbiome. You can do this by increasing your consumption of fermented food (such as yogurt) and consuming moderate amounts of fiber-rich vegetables, fruits,, and grains.
Several studies have shown Consuming too much red meat or processed meat can increase your risk of developing colorectal carcinoma. After being fermented and released by intestinal bacteria, diet residues can enter the colon and cause damage to the colonic cells.
Mediterranean diets that include high-quality vegetables, high quality fats, and high levels of protein can help reduce cholesterol. incidence of colorectal cancer. One reason is that the Mediterranean diet may increase the likelihood of getting cancer. good bacteria You can improve your gut health by cultivating a healthy microbiome.
Tsai said that people with a poor microbiome may not feel the improvements in their health until up to half a years after they switch to a Mediterranean diet. These people should not eat a lot of high-fiber food in one go. These people are more likely to have fewer bacteria capable of decomposing fiber in their intestines. A sudden intake high levels of fiber can cause discomfort. To directly improve their gut microbiome it is recommended that they take probiotics. After some time, they will start to see the effects of diet improvement.
2. Consider taking a probiotic supplement
The overall health of the gut microbiome is a key factor in how much inflammation there is. There is no single strain of bacteria that will improve the microbiome. Diverse types of bacteria must be supplemented simultaneously. Lactobacilli Bifidobacteria. Tsai recommends that you choose probiotics products which contain between five and six types of beneficial bacteria.
3. Continue oral health Good food hygiene
Food hygiene is key to preventing bacteria from forming. E. coli From “entering the mouth and causing illness.” Human health in general includes oral health. It is hard to suppress it. Porphyromonas gingivalis Good intestinal bacteria is not enough; oral hygiene must be maintained.
Dr. Chih Chih Chung, an attending doctor at the Center Union Dental Clinic, Taiwan, believes that effective dental cleaning reduces the amount of bacteria within the mouth. This may indirectly lower the levels of bacteria in our bodies and reduce the chance of developing colorectal carcinoma.
As far as brushing your teeth, the Bass technique is considered to be the most effective. Hold the toothbrush bristles at 45 degrees to your teeth while brushing. This allows the bristles of the toothbrush to gently brush the gums and gingival sulcus.
Chih-Chung recommended that you carry dental floss and use it to clean between your teeth after eating. It is also recommended to have your mouth cleaned and checked every six months. This will help you maintain your oral health.
Camille Su, a health reporter, covers nutrition and other investigative topics. Got a tip to share? [email protected]
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