{"id":2120235,"date":"2023-12-08T19:27:04","date_gmt":"2023-12-09T00:27:04","guid":{"rendered":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/gene-editing-treatment-for-sickle-cell-anemia-is-approved-by-fda\/"},"modified":"2023-12-08T19:32:43","modified_gmt":"2023-12-09T00:32:43","slug":"gene-editing-treatment-for-sickle-cell-anemia-is-approved-by-fda","status":"publish","type":"post","link":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/gene-editing-treatment-for-sickle-cell-anemia-is-approved-by-fda\/","title":{"rendered":"FDA Approves Gene-Editing Treatment for Sickle Cell Anemia"},"content":{"rendered":"<aside class=\"mashsb-container mashsb-main mashsb-stretched\"><div class=\"mashsb-box\"><div class=\"mashsb-count mash-medium\" style=\"&quot;\"><div class=\"counts mashsbcount\">16<\/div><span class=\"mashsb-sharetext\">SHARES<\/span><\/div><div class=\"mashsb-buttons\"><a class=\"mashicon-facebook mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/www.facebook.com\/sharer.php?u=https%3A%2F%2Fwww.conservativenewsdaily.net%2Fbreaking-news%2Fgene-editing-treatment-for-sickle-cell-anemia-is-approved-by-fda%2F\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Facebook<\/span><\/a><a class=\"mashicon-twitter mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/twitter.com\/intent\/tweet?text=&amp;url=https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=2120235&amp;via=ConservNewsDly\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Twitter<\/span><\/a><a class=\"mashicon-subscribe mash-medium mash-nomargin mashsb-noshadow\" href=\"#\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Subscribe<\/span><\/a><div class=\"onoffswitch2 mash-medium mashsb-noshadow\" style=\"display:none\"><\/div><\/div>\n            <\/div>\n                <div style=\"clear:both\"><\/div><\/aside>\n            <!-- Share buttons by mashshare.net - Version: 4.0.47--><p><!DOCTYPE html PUBLIC \"-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\" \"http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\"><br \/>\n<?xml encoding=\"utf-8\" ?><?xml encoding=\"utf-8\" ?><?xml encoding=\"utf-8\" ?><html><body><\/p>\n<div class=\"entry-content\">\n<figure class=\"wp-block-image size-full\"><figcaption class=\"wp-element-caption\">A sign for the\u200d Food \u200dAnd Drug Administration is\u2062 seen\u200c outside of\u2062 the headquarters on July 20, 2020 in White Oak,\u200b Maryland. (Photo by Sarah\u2063 Silbiger\/Getty Images)<\/figcaption><\/figure>\n<h2>OAN\u2019s <a href=\"https:\/\/www.oann.com\/tag\/brooke-mallory\">Brooke Mallory<\/a><br \/>3:57 \u200cPM \u2013 Friday, December 8, 2023<\/h2>\n<p>A ground-breaking gene-editing therapy for <a href=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/white-house-releases-list-of-president-trumps-accomplishments-and-it-is-historic\/\" title=\"White House Releases List of President Trump\u2019s Accomplishments \u2013  And It Is Historic!\">sickle cell disease<\/a>, a debilitating\u2063 ailment that \u2064affects around 100,000 Americans, the majority of whom are people of color\u2062 (POC),\u200d was authorized by the U.S. Food and Drug Administration \u2063(FDA) \u200bon Friday.<\/p>\n<div id=\"div-gpt-ad-1663871513696-art-3\" style=\"min-width: 320px; min-height: 50px; text-align: center;\">  \t<script>  \t\tgoogletag.cmd.push(function() { googletag.display('div-gpt-ad-1663871513696-art-3'); });  \t<\/script>  <\/div>\n<div class=\"ad-slot__ad-label\">Advertisement<\/div>\n<\/p>\n<p>The\u200c therapy claims to be able\u200b to repair the disease-causing gene.<\/p>\n<p>For Johnny Lubin, a 15-year-old from Connecticut who\u2063 has seen the crippling symptoms of the\u200c condition,\u2064 the discovery provides a\u2064 glimmer of \u2063hope. Since birth, he has struggled with excruciating pain\u2064 and health issues related to his sickle cell gene,\u2064 which he genetically received from\u2063 both of his parents.<\/p>\n<p>Being typically shaped like\u2062 \u201cdoughnuts,\u201d red blood cells bend into stiff sickle \u2064shapes\u2063 that clog \u2062blood vessels and impair the body\u2019s ability to\u2062 absorb oxygen.<\/p>\n<p>Physicians \u2063had informed Lubin that he would not live past the age of 40.<\/p>\n<blockquote class=\"wp-block-quote\">\n<p>\u201cI was starting \u200dto get a little bit scared. Like, I actually did want\u200d to live past 40,\u201d he said.<\/p>\n<\/blockquote>\n<p>Lubin was in and out of hospitals \u200cfor almost \u200cten years. He\u2064 claimed that he would keep\u2064 track of the\u2063 number of times he visited each hospital \u200droom, and \u2064that one \u200bday he\u2062 discovered he had visited\u200c every room on the floor.<\/p>\n<p>When Fabienne and J.R. Lubin, Johnny\u2019s parents, found\u200d out \u2062about a state-of-the-art clinical study\u200d utilizing gene editing\u2014a procedure that does not require \u2063a donor\u2014they were desperate for a \u200bcure.<\/p>\n<p>Lubin\u200c first had chemotherapy to help eradicate \u200cthe aberrant cells after stem cells were taken out\u200c of his bone marrow.<\/p>\n<p>The protective form of hemoglobin, a protein that absorbs oxygen from the lungs and distributes it throughout\u200c the body, was then\u200b increased \u2063in a lab using the editing technique known as \u201cCRISPR.\u201d Normally, this protective form of hemoglobin decreases\u200d after birth. After that, the cells were reinfused\u2064 into Lubin\u2019s circulation.<\/p>\n<p>The \u2063leader of pediatric stem cell transplantation \u200dat New York-Presbyterian\/Columbia University Irving \u200dMedical \u2063Center and Johnny\u2019s physician, Dr. Monica Bhatia, explained that altering the cell reprograms it\u2063 to \u2062generate fetal hemoglobin.<\/p>\n<blockquote class=\"wp-block-quote\">\n<p>\u201cIt\u2019s been widely known that fetal hemoglobin\u200d is somewhat protective, and those who have \u200bhigher levels of\u2064 fetal hemoglobin tend to have less\u200d severe symptoms of sickle cell disease,\u201d she said.<\/p>\n<\/blockquote>\n<blockquote class=\"wp-block-quote\">\n<p>\u201cYou\u2019re changing\u200b somebody\u2019s DNA. So obviously, you wanna\u2064 make sure that the corrections you\u2019re making \u2064are, are the ones\u200d you \u200dwant,\u201d Bhatia \u200dadded.<\/p>\n<\/blockquote>\n<p>Lubin now has much improved health and \u2063the possibility of living a \u200dlonger life after a difficult \u200cfive weeks in the hospital and \u200da \u200bsix-month leave from school.<\/p>\n<blockquote class=\"wp-block-quote\">\n<p>\u201cI thought that was pretty cool how I \u200dhave like new cells, and \u200cI honestly hoped, you know, I could get, \u200cyou \u200dknow,\u2064 some super \u2063powers from it, you know,\u200b maybe become a superhero, \u200byou know, like\u200c genetically engineered,\u201d Lubin said. <\/p>\n<\/blockquote>\n<p>Vertex Pharmaceuticals and CRISPR Therapeutics, located in Boston, developed the medication known as Casgevy.<\/p>\n<p>Before \u200bthe specialists declare the medication to be a guaranteed cure, patients\u200b must be\u2064 monitored for \u200ban extended period of time. Although gene editing \u200cmay not\u2064 be suitable for every sickle cell disease patient, it is anticipated to cost several million dollars per patient.<\/p>\n<p>However, it would not stop the gene from being inherited by future generations.<\/p>\n<p>Stay informed! Receive breaking news blasts directly to\u2062 your inbox \u2064for free. Subscribe here. <a href=\"https:\/\/www.oann.com\/alerts\">https:\/\/www.oann.com\/alerts<\/a><\/p>\n<\/p>\n<div id=\"rc-widget-10bad2\" data-rc-widget data-widget-host=\"habitat\" data-endpoint=\"\/\/trends.revcontent.com\" data-widget-id=\"278641\"><\/div>\n<p class=\"dpsp-share-text\" style=\"margin-bottom:10px\"> \t\t \t\tShare\u200c this\u2062 post!\t<\/p>\n<\/p><\/div>\n<div class=\"entry-content\">\n<p>From a massive drop in support among\u2063 the Muslim community \u200bto Biden\u2019s \u200dre-election campaign\u200c scrambling to save face. One America\u2019s Monica Paige breaks\u2064 down the week at\u200c the Biden White House.<\/p>\n<\/p><\/div>\n<div class=\"entry-content\">\n<p>A\u00a0unique store \u200bin\u2064 Scottsboro, Alabama,\u00a0called unclaimed \u2062baggage, leaves little to\u200d the imagination with their name. <\/p>\n<\/p><\/div>\n<div class=\"entry-content\">\n<p>The\u2064 President\u2019s \u200bson Hunter is slammed with nine new tax-related \u200ccharges in a new indictment.<\/p>\n<\/p><\/div>\n<div class=\"entry-content\">\n<p>West Virginia and Indiana co-lead an amicus brief asking\u2062 the Michigan Court\u200d Of\u200c Appeals to keep 45th President \u200bDonald Trump on the ballot in \u200dboth the primary and general elections.<\/p>\n<\/p><\/div>\n<div class=\"entry-content\">\n<p>Amazon.com \u2064asked a federal court to dismiss a U.S. government antitrust lawsuit which \u200caccuses the company of using\u200d illegal strategies to \u2062boost profits at its online retail empire.<\/p>\n<\/p><\/div>\n<div class=\"entry-content\">\n<p>More than 10 million people have signed \u2062up for X in December, X CEO Linda Yaccarino said in a post on the social media platform.<\/p>\n<\/p><\/div>\n<div class=\"entry-content\">\n<p>Alphabet shares ended\u200b 5.3% higher on Thursday as \u200cWall Street cheered the \u200blaunch of Gemini.<\/p>\n<\/p><\/div>\n<div class=\"entry-content\">\n<p>Meta Platforms\u200c will add invisible watermarking\u2064 to its text-to<a href=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/attorney-speaks-on-memories-of-friend-sandra-day-o-connor\/\" title=\"Attorney reflects on memories of Sandra Day O'Connor\">-image generation product \u2062imagine<\/a> with Meta AI chatbot in the coming weeks to \u2062enhance\u2064 transparency.<\/p>\n<\/p><\/div>\n<p> rnrn  <\/p>\n<h2> What are the \u2062ethical considerations associated with gene-editing therapy for sickle cell disease?<\/h2>\n<p><span>  \u2064To our newsletter for the latest\u200c updates.<\/p>\n<h3>The \u200bSignificance of Gene-Editing Therapy<\/h3>\n<p>The authorization of\u2062 gene-editing\u2062 therapy by the FDA marks a significant breakthrough in the \u200ctreatment of \u2062sickle cell\u200b disease. This\u200b debilitating ailment, which primarily affects\u2064 people of \u200dcolor, \u200chas caused immense suffering and decreased life \u2064expectancy for thousands of\u200c Americans.\u200c With the new therapy, there is hope \u2064for a better quality of life and a longer lifespan for individuals like Johnny Lubin.<\/p>\n<p>Sickle cell disease \u2064is characterized by red blood\u2064 cells that are abnormally shaped, resembling sickles. These misshapen\u200c cells clog blood vessels and hinder the \u2063body&#8217;s\u2063 ability to absorb \u200boxygen. People \u2063with sickle cell disease \u2062experience excruciating pain and are\u2064 prone to various health\u2063 issues. \u2063Many\u200c have been told that their life expectancy \u200bis limited,\u2064 causing\u2064 anxiety and fear.<\/p>\n<p>However, gene editing offers \u2064a promising solution. \u200dThe therapy works by repairing the disease-causing gene \u2063and increasing the production of a protective form of\u2063 hemoglobin \u2062known \u2062as fetal \u2064hemoglobin. Research has shown \u2062that higher \u200clevels of fetal hemoglobin can lead to milder symptoms of sickle cell disease.<\/p>\n<p>The successful implementation of gene\u200b editing \u200cin Johnny Lubin&#8217;s case is a testament to its potential. Lubin, who had been in and out of hospitals for years, saw a\u2063 significant improvement in his health after \u200bundergoing the\u2063 therapy. \u200cThe \u200cprocedure involved chemotherapy\u200d to eliminate aberrant cells and \u200cincrease fetal hemoglobin levels, followed \u2062by the reinfusion of modified cells into \u2063his \u200dbloodstream.<\/p>\n<h3>Ethical Considerations and\u2064 Future Prospects<\/h3>\n<p>While the approval of gene-editing therapy brings hope for many individuals suffering from\u200c sickle cell disease, \u200cthere are ethical considerations that need to be\u200c addressed. Altering a person&#8217;s DNA\u200d raises concerns about \u2064the long-term effects and the potential\u200c unintended consequences of manipulating genes.<\/p>\n<p>Medical\u200c professionals and researchers emphasize the importance of ensuring that gene corrections are\u2064 accurate and targeted. This highlights\u200c the need for \u2064rigorous testing and monitoring of patients who undergo gene\u200d editing. The therapy&#8217;s high\u2064 cost also poses \u2063a significant barrier to accessibility, with estimates suggesting a price tag of several million dollars \u200dper patient.<\/p>\n<p>Additionally, it&#8217;s important \u2062to note that\u2062 gene editing does not eliminate the possibility\u200c of the disease being inherited by\u2064 future generations. Therefore, comprehensive \u2064genetic counseling and education should accompany the therapy to help <a href=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/federal-government-relaunches-covid-19-testing-program\/\" title=\"Federal Government restarts COVID-19 testing initiative.\">individuals make informed decisions<\/a> about \u2062family planning.<\/p>\n<p>Despite these challenges, the authorization of gene-editing therapy for sickle cell disease is a major step forward in the medical field. \u200cIt\u2062 offers hope, improved quality of \u200blife, and the potential for a longer lifespan \u200dfor those\u2062 affected by the disease.<\/p>\n<h3>Conclusion<\/h3>\n<p>The approval of gene-editing therapy by the FDA provides a glimmer of hope for individuals living with sickle cell \u2064disease. By repairing the \u200ddisease-causing gene \u200dand increasing the production\u200d of protective hemoglobin, the\u2062 therapy\u200d offers the possibility of a better quality of\u2064 life and increased life \u200dexpectancy.<\/p>\n<p>However,\u2063 ethical considerations and the high cost of the therapy must be addressed to ensure that it is\u2064 accessible and safe for all \u2064patients. Long-term monitoring and genetic counseling are essential components\u200c of \u2064the treatment process.<\/p>\n<p>As research in \u2063gene editing continues\u200c to advance, there \u200dis hope for further breakthroughs in the treatment of genetic \u200bdisorders. \u2064The authorization\u2062 of this therapy is a significant milestone, bringing \u200cus closer to a\u200c future where genetic diseases can be effectively managed and \u200cpotentially cured.<\/p>\n<h3>Sources:<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.oann.com\/tag\/brooke-mallory\">OAN\u2019s Brooke Mallory<\/a><\/li>\n<li><a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-authorizes-new-gene-editing-therapy-sickle-cell-disease-000\">U.S. Food and Drug Administration<\/a><\/li>\n<li><a href=\"https:\/\/apnews.com\/article\/connecticut-new-york-columbia-university-john-b-h-lisi-childrens-hospital-9ddfed0b620b3a5c539931e0f3f369d3\">AP News<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Whom are of African descent, has been approved by the Food and Drug Administration (FDA). This therapy offers hope for those suffering from sickle cell disease, as it utilizes gene-editing techniques to potentially cure the condition. The FDA&#8217;s approval marks a significant milestone in the fight against this debilitating disease<\/p>\n","protected":false},"author":1866,"featured_media":2120236,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mo_disable_npp":"","fifu_image_url":"https:\/\/cndimages.nyc3.digitaloceanspaces.com\/breaking-news\/wp-content\/uploads\/2021\/01\/IMG_2758-scaled-1.jpg","fifu_image_alt":"","footnotes":""},"categories":[542],"tags":[],"class_list":["post-2120235","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-oann"],"fifu_image_url":"https:\/\/cndimages.nyc3.digitaloceanspaces.com\/breaking-news\/wp-content\/uploads\/2021\/01\/IMG_2758-scaled-1.jpg","_links":{"self":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/2120235","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/users\/1866"}],"replies":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/comments?post=2120235"}],"version-history":[{"count":0,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/2120235\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media\/2120236"}],"wp:attachment":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media?parent=2120235"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/categories?post=2120235"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/tags?post=2120235"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}