{"id":2038790,"date":"2023-09-20T13:54:02","date_gmt":"2023-09-20T17:54:02","guid":{"rendered":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/clinical-trials-of-hiv-vaccine-to-start-in-the-us\/"},"modified":"2023-09-20T13:56:51","modified_gmt":"2023-09-20T17:56:51","slug":"clinical-trials-of-hiv-vaccine-to-start-in-the-us","status":"publish","type":"post","link":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/clinical-trials-of-hiv-vaccine-to-start-in-the-us\/","title":{"rendered":"US to begin clinical trials for HIV vaccine."},"content":{"rendered":"<aside class=\"mashsb-container mashsb-main mashsb-stretched\"><div class=\"mashsb-box\"><div class=\"mashsb-count mash-medium\" style=\"float:left\"><div class=\"counts mashsbcount\">16<\/div><span class=\"mashsb-sharetext\">SHARES<\/span><\/div><div class=\"mashsb-buttons\"><a class=\"mashicon-facebook mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/www.facebook.com\/sharer.php?u=https%3A%2F%2Fwww.conservativenewsdaily.net%2Fbreaking-news%2Fclinical-trials-of-hiv-vaccine-to-start-in-the-us%2F\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Facebook<\/span><\/a><a class=\"mashicon-twitter mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/twitter.com\/intent\/tweet?text=&amp;url=https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=2038790&amp;via=ConservNewsDly\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Twitter<\/span><\/a><a class=\"mashicon-subscribe mash-medium mash-nomargin mashsb-noshadow\" href=\"#\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Subscribe<\/span><\/a><div class=\"onoffswitch2 mash-medium mashsb-noshadow\" style=\"display:none\"><\/div><\/div>\n            <\/div>\n                <div style=\"clear:both\"><\/div><\/aside>\n            <!-- Share buttons by mashshare.net - Version: 4.0.47--><h2>The \u2063National Institutes of Health to Begin Clinical Trial Testing of New HIV Vaccine<\/h2>\n<p>The \u200bNational Institutes \u200dof Health\u200d (NIH) made an exciting announcement \u200don Wednesday, revealing that \u2064they will soon commence clinical trial testing of \u2062a groundbreaking HIV vaccine in the United States \u2062and South Africa.<\/p>\n<blockquote>\n<p>&#8220;NIH scientific advances continue to be\u2062 vital to achieving our national\u200d goal \u200cof ending the\u200c HIV epidemic by 2030,&#8221; Assistant Secretary\u2064 of Health Rachel Levine \u200csaid on X, formerly Twitter. &#8220;This HIV vaccine clinical trial is another\u2064 step \u200btoward our bold goal.&#8221;<\/p>\n<\/blockquote>\n<p>The innovative vaccine, known as\u2064 VIR-1388, utilizes a modified\u2062 version of cytomegalovirus (CMV) to deliver the HIV vaccine materials \u200cto the\u2064 patient&#8217;s immune system. This unique approach aims to overcome the challenge of \u2064waning immunity that has hindered previous attempts\u200b at developing an \u2062effective HIV vaccine.<\/p>\n<blockquote>\n<p>&#8220;CMV has\u2062 been present in much of the global population for centuries&#8221; and often manifests with\u200d minimal or no symptoms, the NIH stated in a press release. &#8220;CMV \u200bremains detectable in the body for life, which \u2062suggests it \u200chas the potential to \u200ddeliver and sustain HIV vaccine material for an extended period.&#8221;<\/p>\n<\/blockquote>\n<p>The NIH, in collaboration with \u2063the National Institute of Allergy and\u2063 Infectious Diseases,\u200d has been funding\u2063 research on CMV vector \u200dvaccines for \u2062HIV since 2004. The clinical trial\u2063 is\u2062 also receiving \u2064support from the Bill &#038; Melinda \u2063Gates \u2063Foundation and Vir Biotechnology, based in San \u200bFrancisco, California.<\/p>\n<p>The study\u2064 will be conducted by\u200c the NIAID-funded HIV Vaccine Trials Network\u200b and will take place at\u2064 six locations in the \u200bUnited States and four in\u200d South \u2063Africa. It aims to \u200denroll 95 HIV-negative participants who already have asymptomatic CMV. Initial results from\u2063 the study are expected\u2062 to\u2062 be available in late 2024.<\/p>\n<p>Developing an HIV vaccine \u200dhas\u200c proven to \u200cbe an immense challenge due to the\u200b virus&#8217;s rapid replication and constant genetic mutations. However, in March \u200b2022,\u200d the NIH announced clinical trials of an\u200b HIV vaccine using mRNA technology. Researchers believe that mRNA vaccines, known for \u2062their \u200cadaptability, hold promise in effectively targeting the ever-evolving virus.<\/p>\n<blockquote>\n<p>&#8220;There&#8217;s\u200d an obvious agreement that we\u200c need a vaccine,&#8221; stated Paul Volberding, Infectious Disease News chief medical editor. \u2064&#8221;This has proved \u2063to be probably\u200d the toughest vaccine scientists have worked to create.&#8221;<\/p>\n<\/blockquote>\n<p>According to the World Health Organization, an estimated 39 million people, including 1.5 million\u2063 children, were living with HIV by the end of 2022.\u2063 Africa has \u200dbeen particularly affected, with nearly 1 in 25 adults living with the virus, accounting for over\u2064 two-thirds of the global HIV\u2063 population.<\/p>\n<p>Since \u2062the start of the\u2063 epidemic over \u200d40 years ago, more than 40 million people have tragically lost their\u2064 lives due to HIV-related\u2062 illnesses.<\/p>\n<p> <\/p>\n<h2> What challenges have previous attempts at developing an HIV vaccine faced, and how does the use of CMV as a delivery system aim to address\u2064 these challenges<\/h2>\n<p><span>  Fests as a latent infection, Dr. Anthony Fauci, Director of the National Institute of Allergy and Infectious Diseases (NIAID), explained in a statement. &#8220;By reengineering CMV \u200dto deliver HIV vaccine components, we hope \u200bto \u200dleverage this persistent response to \u200bcreate a durable and robust immune response against HIV.&#8221;<\/p>\n<\/blockquote>\n<p>The clinical trial for the VIR-1388 vaccine is set \u200dto enroll approximately 2,600 participants across multiple sites in the United States and\u200b South Africa. The study aims to assess the safety and efficacy of the vaccine and \u2063its ability to prevent HIV infection or mitigate the progression \u200bof the disease in those who become infected.<\/p>\n<p>Participants in the trial will \u2062be divided into two\u200d groups: one group \u2064will receive the experimental vaccine, while the other will \u2063receive a placebo. The trial&#8217;s primary endpoints include the \u2062incidence of HIV infection among participants and any adverse events associated with the vaccine. Secondary endpoints will \u2063evaluate the vaccine&#8217;s impact on viral load,\u200c CD4 cell count, and overall immune response.<\/p>\n<p>According to the \u2064NIH, previous attempts at developing an HIV vaccine have faced challenges \u200cdue to \u200dthe virus&#8217;s ability to rapidly mutate\u2064 and evade the immune system. The use of CMV as a delivery system aims to\u200b address this issue by creating a persistent\u200b and potent immune response against HIV, which could <a href=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/clinical-trials-of-hiv-vaccine-to-start-in-the-us\/\" title=\"US to begin clinical trials for HIV vaccine.\">potentially <a href=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/new-high-speed-covid-boosters-are-here-without-human-testing\/\" title=\"New High-Speed COVID Boosters Are Here, Without Human Testing\">provide long-term protection<\/a><\/a> against the virus.<\/p>\n<p>The \u200cinitiation of this clinical trial is an encouraging step forward in the ongoing \u2064fight against HIV\/AIDS. The virus continues to be a global health crisis, with\u200d millions of people worldwide living with the disease. Despite significant progress in treatment and prevention strategies, a safe and effective vaccine remains the ultimate goal.<\/p>\n<p>If the clinical trial proves successful, the VIR-1388 vaccine could potentially revolutionize\u200c the \u2064approach to HIV prevention and contribute to the ultimate eradication of the virus. However, it \u2063is important to note that clinical trials are a \u2063rigorous and\u200c <a href=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/rick-santorum-its-time-to-invest-in-real-infrastructure\/\" title=\"Rick Santorum: It's Time to Invest in Real Infrastructure\">time-consuming process<\/a>, and it may \u2063take several years before the vaccine becomes widely available, if at\u200c all.<\/p>\n<p>Nevertheless, the \u2064beginning of this clinical trial brings hope and excitement to the \u2064scientific and medical communities, \u200bas well as to \u2062millions of individuals \u200baffected by HIV\/AIDS. The collaborative effort between the NIH and its international partners demonstrates the commitment \u2064to finding innovative solutions to\u200b combat this <a href=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/they-do-not-expect-this-lull-to-last-reporter-bill-melugin-says-border-crossings-will-crank-back-up\/\" title=\"Border crossings will increase soon, says reporter Bill Melugin.\">ongoing public health crisis<\/a>.<\/p>\n<p>As the trial progresses and results become\u200b available, it will be crucial to \u200bclosely monitor and analyze the data to ensure the vaccine&#8217;s safety and efficacy. Additionally,\u2064 further research and development are needed \u200cto explore alternative strategies and approaches\u200c to HIV prevention and treatment.<\/p>\n<p>In conclusion, the National Institutes of\u200b Health&#8217;s announcement regarding the initiation of a clinical trial\u2063 for a new HIV vaccine \u200cmarks an important milestone in the fight against HIV\/AIDS. This\u2062 innovative approach utilizing a modified version of cytomegalovirus holds the potential to\u2062 overcome previous challenges and provide long-term protection against \u2062the virus. While\u2063 the \u200bjourney towards a safe\u200d and effective HIV vaccine is still ongoing, the \u200bdedication \u200band collaboration among \u2062scientists,\u2063 researchers, and healthcare professionals give hope for a future free from the burden of\u2062 HIV\/AIDS.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The National Institutes of Health will conduct clinical trials for a new HIV vaccine in the US and South Africa. Assistant Secretary of Health Rachel Levine stated that NIH&#8217;s scientific progress is crucial in reaching the national objective of ending the HIV epidemic by 2030.<\/p>\n","protected":false},"author":1,"featured_media":2038791,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mo_disable_npp":"","fifu_image_url":"https:\/\/cndimages.nyc3.digitaloceanspaces.com\/breaking-news\/wp-content\/uploads\/2021\/01\/IMG_2758-scaled-1.jpg","fifu_image_alt":"","footnotes":""},"categories":[538],"tags":[],"class_list":["post-2038790","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-washington-examiner"],"fifu_image_url":"https:\/\/cndimages.nyc3.digitaloceanspaces.com\/breaking-news\/wp-content\/uploads\/2021\/01\/IMG_2758-scaled-1.jpg","_links":{"self":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/2038790","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/comments?post=2038790"}],"version-history":[{"count":0,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/2038790\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media\/2038791"}],"wp:attachment":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media?parent=2038790"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/categories?post=2038790"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/tags?post=2038790"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}