{"id":203673,"date":"2021-03-09T10:30:12","date_gmt":"2021-03-09T15:30:12","guid":{"rendered":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=203673"},"modified":"2021-03-09T10:30:13","modified_gmt":"2021-03-09T15:30:13","slug":"study-pfizer-vaccine-successful-against-third-variant-virus","status":"publish","type":"post","link":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/study-pfizer-vaccine-successful-against-third-variant-virus\/","title":{"rendered":"Study: Pfizer Vaccine Successful Against Third Variant Virus"},"content":{"rendered":"<aside class=\"mashsb-container mashsb-main mashsb-stretched\"><div class=\"mashsb-box\"><div class=\"mashsb-count mash-medium\" style=\"&quot;\"><div class=\"counts mashsbcount\">16<\/div><span class=\"mashsb-sharetext\">SHARES<\/span><\/div><div class=\"mashsb-buttons\"><a class=\"mashicon-facebook mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/www.facebook.com\/sharer.php?u=https%3A%2F%2Fwww.conservativenewsdaily.net%2Fbreaking-news%2Fstudy-pfizer-vaccine-successful-against-third-variant-virus%2F\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Facebook<\/span><\/a><a class=\"mashicon-twitter mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/twitter.com\/intent\/tweet?text=&amp;url=https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=203673&amp;via=ConservNewsDly\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Twitter<\/span><\/a><a class=\"mashicon-subscribe mash-medium mash-nomargin mashsb-noshadow\" href=\"#\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Subscribe<\/span><\/a><div class=\"onoffswitch2 mash-medium mashsb-noshadow\" style=\"display:none\"><\/div><\/div>\n            <\/div>\n                <div style=\"clear:both\"><\/div><\/aside>\n            <!-- Share buttons by mashshare.net - Version: 4.0.47--><div><img decoding=\"async\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2021\/02\/Pfizer-1.jpg?w=1200&amp;h=800&amp;ixlib=react-9.0.3\" class=\"ff-og-image-inserted\" \/><\/div>\n<p>Research conducted by scientists at the University of Texas Medical Branch in Galveston, Texas, indicates that the Pfizer COVID-19 vaccine has a strong capability of countering variants not only from the U.K. and South Africa, but the variant from Brazil. The scientists had previously asserted in February that the vaccine was successful in countering the variants from the U.K. and South Africa.<\/p>\n<p>The scientists wrote a <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMc2102017\">letter<\/a> to the New England Journal of Medicine in which they asserted that serum samples were taken from people either two weeks or four weeks after the second dose of the vaccine had been administered.&nbsp;The scientists explained:<\/p>\n<blockquote>\n<p><em>New, highly transmissible SARS-CoV-2 variants that were first detected in the United Kingdom (B.1.1.7 lineage), South Africa (B.1.351 lineage), and Brazil (P.1 lineage) with mutations in the&nbsp;S&nbsp;gene are spreading globally. To analyze effects on neutralization elicited by BNT162b2, we engineered&nbsp;S&nbsp;mutations from each of the three new lineages into USA-WA1\/2020, a relatively early isolate of the virus from January 2020. \u2026 We thereby produced three recombinant viruses representing each of these lineages and two additional ones in which we engineered subsets of mutations of the B.1.351 lineage.<\/em><\/p>\n<p><em>Thus, the first recombinant virus had all the mutations found in the&nbsp;S&nbsp;gene in the B.1.1.7 lineage (B.1.1.7-spike), the second had all the mutations found in the&nbsp;S&nbsp;gene in the P.1 lineage (P.1-spike), the third had all the mutations found in the&nbsp;S&nbsp;gene in the B.1.351 lineage (B.1.351-spike), the fourth had an N-terminal domain deletion found in the B.1.351 lineage and the globally dominant D614G substitution (B.1.351-\u2206242-244+D614G), and the fifth had the three mutations from the B.1.351 lineage affecting amino acids in the receptor-binding site (K417N, E484K, and N501Y) and a D614G substitution (B.1.351-RBD+D614G).<\/em><\/p>\n<\/blockquote>\n<p>\u201cWhile the research needs to be validated with real-world data, it offers another reason for&nbsp;optimism&nbsp;that the Covid vaccines are generally performing well against variants of the virus,\u201d <a href=\"https:\/\/www.bloomberg.com\/news\/articles\/2021-03-09\/pfizer-biontech-covid-shot-neutralizes-brazilian-strain-in-lab\">Bloomberg<\/a> reported.<\/p>\n<p>The researchers\u2019 letter explained, \u201cAll the serum samples efficiently neutralized USA-WA1\/2020 and all the viruses with variant spikes. Almost all of them did so at titers higher than 1:40.\u201d<\/p>\n<p>They also highlighted the limitations of the study:<\/p>\n<blockquote>\n<p><em>Limitations of the study include the potential for mutations to alter neutralization by affecting spike function rather than antigenicity. Therefore, each neutralization assay with a different target virus is unique, and comparisons between neutralization titers from different assays should be interpreted with caution. \u2026 Ultimately, conclusions about vaccine-mediated protection that are extrapolated from neutralization or T-cell data must be validated by real-world evidence collected in regions where the SARS-CoV-2 variants are circulating.<\/em><\/p>\n<\/blockquote>\n<p>In early February, the Texas scientists <a href=\"https:\/\/www.dailywire.com\/news\/studies-find-pfizer-vaccine-neutralizes-variant-covid-viruses\/\">released results<\/a> of testing the Pfizer vaccine on variants from the U.K. and South Africa. They <a href=\"https:\/\/www.nature.com\/articles\/s41591-021-01270-4\">explained<\/a>, \u201cUsing an infectious complementary DNA (cDNA) clone of SARS-CoV-2 we engineered three spike mutant viruses on the genetic background of clinical strain USA-WA1\/2020. Mutant N501Y virus contains the N501Y mutation that is shared by both the UK and SA variants.&nbsp;\u2026 Mutant \u039469\/70\u2009+\u2009N501Y\u2009+\u2009D614G virus contains two additional changes present in the UK variants \u2026 Mutant E484K\u2009+\u2009N501Y\u2009+\u2009D614G virus additionally contains the E484K substitution, which is also located in the viral RBD.\u201d<\/p>\n<p>\u201cA limitation of the current study is that the engineered viruses do not include the full set of spike mutations found in the UK or SA variants,\u201d the researchers noted. \u201cNevertheless, preserved neutralization of N501Y, \u039469\/70\u2009+\u2009N501Y\u2009+\u2009D614G and E484K\u2009+\u2009N501Y\u2009+\u2009D614G viruses by BNT162b2 vaccine-elicited human sera is consistent with preserved neutralization of a panel of 15 pseudoviruses bearing spikes with other single mutations found in circulating SARS-CoV-2 strains.\u201d<\/p>\n<p><em>The Daily Wire is one of America\u2019s fastest-growing conservative media companies and counter-cultural outlets for news, opinion, and entertainment. Get inside access to The Daily Wire by becoming a<\/em> <a href=\"https:\/\/www.dailywire.com\/subscribe\"><em>member<\/em><\/a><em>.&nbsp;<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research conducted by scientists at the University of Texas Medical Branch in Galveston, Texas, indicates that the Pfizer COVID-19 vaccine has a strong capability of countering variants not only from &#8230;<\/p>\n","protected":false},"author":1,"featured_media":2310346,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mo_disable_npp":"","fifu_image_url":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2021\/02\/Pfizer-1.jpg?w=1200&h=800&ixlib=react-9.0.3","fifu_image_alt":"Study: Pfizer Vaccine Successful Against Third Variant Virus","footnotes":""},"categories":[],"tags":[],"class_list":["post-203673","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"fifu_image_url":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2021\/02\/Pfizer-1.jpg?w=1200&h=800&ixlib=react-9.0.3","fifu_image_alt":"Study: Pfizer Vaccine Successful Against Third Variant Virus","_links":{"self":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/203673","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/comments?post=203673"}],"version-history":[{"count":0,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/203673\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media\/2310346"}],"wp:attachment":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media?parent=203673"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/categories?post=203673"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/tags?post=203673"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}