{"id":1913134,"date":"2023-04-11T13:28:18","date_gmt":"2023-04-11T17:28:18","guid":{"rendered":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/what-causes-insulin-resistance\/"},"modified":"2023-04-11T13:31:10","modified_gmt":"2023-04-11T17:31:10","slug":"what-causes-insulin-resistance","status":"publish","type":"post","link":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/what-causes-insulin-resistance\/","title":{"rendered":"What Causes Insulin Resistance?"},"content":{"rendered":"<aside class=\"mashsb-container mashsb-main mashsb-stretched\"><div class=\"mashsb-box\"><div class=\"mashsb-count mash-medium\" style=\"&quot;\"><div class=\"counts mashsbcount\">8<\/div><span class=\"mashsb-sharetext\">SHARES<\/span><\/div><div class=\"mashsb-buttons\"><a class=\"mashicon-facebook mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/www.facebook.com\/sharer.php?u=https%3A%2F%2Fwww.conservativenewsdaily.net%2Fbreaking-news%2Fwhat-causes-insulin-resistance%2F\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Facebook<\/span><\/a><a class=\"mashicon-twitter mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/twitter.com\/intent\/tweet?text=&amp;url=https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=1913134&amp;via=ConservNewsDly\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Twitter<\/span><\/a><a class=\"mashicon-subscribe mash-medium mash-nomargin mashsb-noshadow\" href=\"#\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Subscribe<\/span><\/a><div class=\"onoffswitch2 mash-medium mashsb-noshadow\" style=\"display:none\"><\/div><\/div>\n            <\/div>\n                <div style=\"clear:both\"><\/div><\/aside>\n            <!-- Share buttons by mashshare.net - Version: 4.0.47--><div>\n<p>Prediabetes and Type 2 diabetes are caused by a drop in insulin sensitivity blamed on \u201cintramyocellular lipid,\u201d the buildup of fat inside our muscle cells.<\/p>\n<p>\t\t<iframe loading=\"lazy\" width=\"671\" height=\"377\" src=\"https:\/\/www.youtube.com\/embed\/Aw8hufhIDu0?wmode=transparent&#038;wmode=opaque\" allowfullscreen><\/iframe> \t\t<\/p>\n<p><i>Below is an approximation of this video\u2019s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.<\/i><\/p>\n<p>Studies dating back nearly a century noted a striking finding. If you take young, healthy people and split them up into two groups, half on a fat-rich diet, and the other half on a carb-rich diet, within just two days, this is what happens: The glucose intolerance skyrockets in the fatty diet group.<\/p>\n<p>In response to the same sugar water challenge, the group that had been shoveling in fat ended up with twice the blood sugar. As the amount of fat in the diet goes up, one\u2019s blood sugar spikes. It would take scientists nearly seven decades to unravel this mystery, but it would end up holding the key to our current understanding of the cause of Type 2 diabetes.<\/p>\n<p>When\u00a0athletes carb-load before a race, they\u2019re trying to build up the fuel supply within their muscles. They\u00a0break down the starch into glucose in their\u00a0digestive tract. It circulates as blood glucose\u2014blood sugar\u2014and is taken up by our muscles, to be stored and burned for energy.<\/p>\n<p>Blood sugar, though, is like a vampire. It needs an invitation to come into our cells. And, that invitation is insulin. Here\u2019s a muscle cell. Here\u2019s some blood sugar outside, waiting patiently to come in. Insulin is the key that unlocks the door to let sugar in our\u00a0blood enter the muscle cell.<\/p>\n<p>When insulin attaches to the insulin receptor, it activates an enzyme, which activates another enzyme, which activates two more enzymes, which finally activates glucose transport, which\u00a0acts as a gateway for glucose to enter the cell. So, insulin is the key that unlocks the door into our muscle cells.<\/p>\n<p>What if there was no insulin, though? Well, blood sugar would be stuck out in the bloodstream, banging on the door to our muscles, and not able to get inside. And so, with nowhere to go, sugar levels would rise and rise.<\/p>\n<p>That\u2019s what happens in Type 1 diabetes\u2014the cells in the pancreas that make insulin get destroyed, and without insulin, sugar in the blood can\u2019t get out of the blood into the muscles, and blood sugar rises.<\/p>\n<p>But, there\u2019s a second way we could end up with high blood sugar. What if there\u2019s enough insulin, but the insulin doesn\u2019t work? The key is there, but something\u2019s gummed up the lock. This is called insulin resistance. Our muscle cells become resistant to the effect of insulin. What\u2019s gumming up the door locks on our muscle cells, preventing insulin from letting sugar\u00a0in? Fat. [It\u2019s] what\u2019s called intramyocellular lipid, or fat inside our muscle cells.<\/p>\n<p>Fat in the bloodstream can build up inside the muscle cells, and create toxic fatty breakdown products and free radicals that can block the signaling pathway process. So, no matter how much insulin we have out in our blood, it\u2019s not able to open the glucose gates, and blood sugar levels build up in the blood.<\/p>\n<p>This mechanism, by which fat (specifically saturated fat) induces insulin resistance, wasn\u2019t known until fancy MRI techniques were developed to see what was happening inside people\u2019s muscles as fat was infused into their bloodstream. And, that\u2019s how scientists found that elevation of fat levels in the blood \u201ccauses insulin resistance by inhibition of glucose transport\u201d into the muscles.<\/p>\n<p>And, this can happen within just three hours. One hit of fat can start causing insulin resistance, inhibiting glucose uptake after just 160 minutes.<\/p>\n<p>Same thing happens to adolescents. You infuse fat into their bloodstream. It builds up in their muscles and decreases their insulin sensitivity\u2014showing that increased fat in the blood can be\u00a0an important contributor to insulin resistance.<\/p>\n<p>Then, you can do the opposite experiment. Lower the level of fat in people\u2019s blood, and the insulin resistance comes right down. Clear the fat out of the blood, and you can clear the sugar out of the blood. So, that explains this finding. On the high-fat diet\u2014the ketogenic diet\u2014insulin doesn\u2019t work as well. Our bodies are insulin-resistant.<\/p>\n<p>But, as the amount of fat in our diet gets lower and lower, insulin works better and better. This is a clear demonstration that the sugar tolerance of even healthy individuals can be \u201cimpaired by administering a low-carb, high-fat diet.\u201d But, we can decrease insulin resistance\u2014the cause of prediabetes, the cause of Type 2 diabetes\u2014by decreasing saturated fat intake.<\/p>\n<p><em>Republished from\u00a0<a href=\"https:\/\/nutritionfacts.org\/\" target=\"_blank\" rel=\"noopener\">NutritionFacts.org<\/a><\/em><\/p>\n<p><strong>Sources cited<\/strong><\/p>\n<ul>\n<li><em><cite><a title=\"H P Himsworth. The dietetic factor determining the glucose tolerance and senility to insulin of healthy men. Clinical Science 2, 67-94.\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1394223\/\" target=\"_blank\" rel=\"noopener\">H P Himsworth. The dietetic factor determining the glucose tolerance and senility to insulin of healthy men. Clinical Science 2, 67-94.<\/a><\/cite><\/em><\/li>\n<li><em><cite><a title=\"H P Himsworth, E M Marshall. The diet of diabetics prior to the onset of the disease. Clinical Science 2, 95-115, 1935. NA.\" href=\"https:\/\/www.google.com\/url?sa=t&#038;rct=j&#038;q=&#038;esrc=s&#038;source=web&#038;cd=1&#038;cad=rja&#038;uact=8&#038;ved=0ahUKEwiGw4ug-a_YAhVIr1QKHadyAfgQFggoMAA&#038;url=https%3A%2F%2Fwww.cabdirect.org%2Fcabdirect%2Fabstract%2F19351404498&#038;usg=AOvVaw3vrWkc8yF4aTxRloQEzBMd\" target=\"_blank\" rel=\"noopener\">H P Himsworth, E M Marshall. The diet of diabetics prior to the onset of the disease. Clinical Science 2, 95-115, 1935. NA.<\/a><\/cite><\/em><\/li>\n<li><em><cite><a title=\"M Roden, T B Price, G Perseghin, K F Petersen, D L Rothman, G W Cline, G I Shulman. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest. Jun 15, 1996; 97(12): 2859\u20132865.\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC507380\/\" target=\"_blank\" rel=\"noopener\">M Roden, T B Price, G Perseghin, K F Petersen, D L Rothman, G W Cline, G I Shulman. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest. Jun 15, 1996; 97(12): 2859\u20132865.<\/a><\/cite><\/em><\/li>\n<li><em><cite><a title=\"S Lee, C Boesch, J L Kuk, S Arsianian. Effects of an overnight intravenous lipid infusion on intramyocellular lipid content and insulin sensitivity in African-American versus Caucasian adolescents. Metabolism. 2013 Mar;62(3):417-23.\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23122836\" target=\"_blank\" rel=\"noopener\">S Lee, C Boesch, J L Kuk, S Arsianian. Effects of an overnight intravenous lipid infusion on intramyocellular lipid content and insulin sensitivity in African-American versus Caucasian adolescents. Metabolism. 2013 Mar;62(3):417-23.<\/a><\/cite><\/em><\/li>\n<li><em><cite><a title=\"M Roden, K Krssak, H Stingl, S Gruber, A Hofer, C Furnsinn, E Moser, W Waldhausl. Rapid impairment of skeletal muscle glucose transport\/phosphorylation by free fatty acids in humans.\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10334314\" target=\"_blank\" rel=\"noopener\">M Roden, K Krssak, H Stingl, S Gruber, A Hofer, C Furnsinn, E Moser, W Waldhausl. Rapid impairment of skeletal muscle glucose transport\/phosphorylation by free fatty acids in humans.<\/a><\/cite><\/em><\/li>\n<li><em><cite><a title=\"M Krssak, K Falk Petersen, A Dresner, L Dipetro, S M Vogel, D L Rothman, M Roden, G I Shulman. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia. 1999 Jan;42(1):113-6.\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10027589\" target=\"_blank\" rel=\"noopener\">M Krssak, K Falk Petersen, A Dresner, L Dipetro, S M Vogel, D L Rothman, M Roden, G I Shulman. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia. 1999 Jan;42(1):113-6.<\/a><\/cite><\/em><\/li>\n<li><em><cite><a title=\"J Shirley Sweeney. DIETARY FACTORS THAT INFLUENCE THE DEXTROSE TOLERANCE TEST A PRELIMINARY STUDY. JAMA Int Med, Dec, 1927, Vol 40, No. 6.\" href=\"http:\/\/archinte.jamanetwork.com\/article.aspx?articleid=535594\" target=\"_blank\" rel=\"noopener\">J Shirley Sweeney. DIETARY FACTORS THAT INFLUENCE THE DEXTROSE TOLERANCE TEST A PRELIMINARY STUDY. JAMA Int Med, Dec 1927, Vol 40, No. 6.<\/a><\/cite><\/em><\/li>\n<li><em><cite><a title=\"E W Kraegen, G J Cooney. Free fatty acids and skeletal muscle insulin resistance. Curr Opin Lipidol. 2008 Jun;19(3):235-41.\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18460913\" target=\"_blank\" rel=\"noopener\">E W Kraegen, G J Cooney. Free fatty acids and skeletal muscle insulin resistance. Curr Opin Lipidol. 2008 Jun;19(3):235-41.<\/a><\/cite><\/em><\/li>\n<li><em><cite><a title=\"A T Santomauro, G Boden, M E Silva, D M Rocha, FR F Santos, M J Ursich, P G Strassmann, B L Wajchenberg. Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. Diabetes. 1999 Sep;48(9):1836-41.\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/0010480616\" target=\"_blank\" rel=\"noopener\">A T Santomauro, G Boden, M E Silva, D M Rocha, FR F Santos, M J Ursich, P G Strassmann, B L Wajchenberg. Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. Diabetes. 1999 Sep;48(9):1836-41.<\/a><\/cite><\/em><\/li>\n<li><em><cite><a title=\"HP Himsworth. The dietetic factor determining the glucose tolerance and sensitivity to insulin of healthy men. J Physiol. 1934 Mar 29; 81(1): 29\u201348.\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1394223\/\" target=\"_blank\" rel=\"noopener\">HP Himsworth. The dietetic factor determining the glucose tolerance and sensitivity to insulin of healthy men. J Physiol. 1934 Mar 29; 81(1): 29\u201348.<\/a><\/cite><\/em><\/li>\n<\/ul><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Prediabetes and Type 2 diabetes are caused by a drop in insulin sensitivity blamed on \u201cintramyocellular lipid,\u201d the buildup of fat inside our muscle cells. Below is an approximation of this video\u2019s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video. Studies<\/p>\n","protected":false},"author":1,"featured_media":1913135,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mo_disable_npp":"","fifu_image_url":"https:\/\/cndimages.nyc3.digitaloceanspaces.com\/breaking-news\/wp-content\/uploads\/2021\/01\/IMG_2758-scaled-1.jpg","fifu_image_alt":"","footnotes":""},"categories":[547],"tags":[15668,15667],"class_list":["post-1913134","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-the-bongino-report","tag-insulin","tag-resistance"],"fifu_image_url":"https:\/\/cndimages.nyc3.digitaloceanspaces.com\/breaking-news\/wp-content\/uploads\/2021\/01\/IMG_2758-scaled-1.jpg","_links":{"self":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/1913134","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/comments?post=1913134"}],"version-history":[{"count":0,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/1913134\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media\/1913135"}],"wp:attachment":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media?parent=1913134"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/categories?post=1913134"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/tags?post=1913134"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}