{"id":1841917,"date":"2023-02-10T08:35:23","date_gmt":"2023-02-10T13:35:23","guid":{"rendered":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=1841917"},"modified":"2023-02-10T08:38:21","modified_gmt":"2023-02-10T13:38:21","slug":"9-things-you-need-to-know-about-paxlovid","status":"publish","type":"post","link":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/9-things-you-need-to-know-about-paxlovid\/","title":{"rendered":"9 Things You Need to Know About Paxlovid"},"content":{"rendered":"<aside class=\"mashsb-container mashsb-main mashsb-stretched\"><div class=\"mashsb-box\"><div class=\"mashsb-count mash-medium\" style=\"&quot;\"><div class=\"counts mashsbcount\">16<\/div><span class=\"mashsb-sharetext\">SHARES<\/span><\/div><div class=\"mashsb-buttons\"><a class=\"mashicon-facebook mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/www.facebook.com\/sharer.php?u=https%3A%2F%2Fwww.conservativenewsdaily.net%2Fbreaking-news%2F9-things-you-need-to-know-about-paxlovid%2F\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Facebook<\/span><\/a><a class=\"mashicon-twitter mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/twitter.com\/intent\/tweet?text=&amp;url=https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=1841917&amp;via=ConservNewsDly\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Twitter<\/span><\/a><a class=\"mashicon-subscribe mash-medium mash-nomargin mashsb-noshadow\" href=\"#\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Subscribe<\/span><\/a><div class=\"onoffswitch2 mash-medium mashsb-noshadow\" style=\"display:none\"><\/div><\/div>\n            <\/div>\n                <div style=\"clear:both\"><\/div><\/aside>\n            <!-- Share buttons by mashshare.net - Version: 4.0.47-->\n<p>Are you able to tell when <a href=\"https:\/\/www.theepochtimes.com\/t-paxlovid\">Paxlovid<\/a> Should be used to treat <a href=\"https:\/\/www.theepochtimes.com\/t-covid-19\">COVID-19<\/a>? Is it possible to see the differences between the clinical trial data of its phase 2 or 3 clinical trials and the real-life results? Are you aware of the main concern with Paxlovid for its future treatment of COVID-19<\/p>\n<p>Reported to be a so-called \u201cgame-changer\u201d oral antiviral pill to treat COVID-19,\u00a0Paxlovid can prevent hospitalization and death in people who are at high risk of severe COVID-19. You should be aware that research on Paxlovid is not always as it seems.<\/p>\n<p>We will provide a balanced, unbiased review related to Paxlovid\u2019s development history, clinical trial and real-world effectiveness data, and the drug\u2019s advantages and limitations. We will also discuss the relationship between oral antivirals, human immunity, and other drugs.<\/p>\n<h2>Summary of key facts<\/h2>\n<ol>\n<li>FDA Has Not Approved Paxlovid Yet<\/li>\n<li>Paxlovid should be used soon after a virus infection<\/li>\n<li>Clinical Trial: 89 percent Efficacy with Side Effects of Dysgeusia &#038; Diarrhea<\/li>\n<li>Paxlovid Doesn\u2019t Work in Younger Patients<\/li>\n<li>Paxlovid has shown limited effectiveness in a real-world study<\/li>\n<li>Finding \u201cTreatable\u201d Patients Has Proven Challenging<\/li>\n<li>Drug Resistance is a Major Concern<\/li>\n<li>Another Major Concern Is Paxlovid\u2019s Interaction With Other Drugs<\/li>\n<li><span>Natural Immunity Influences the Success Of Paxlovid And Other Antivirals<\/span><\/li>\n<\/ol>\n<p>Pfizer\u2019s\u00a0Paxlovid contains two active ingredients. The first active ingredient is nirmatrelvir PF-07321332, a protease inhibitor that interrupts the viral replication process.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8595904\/#:~:text=The%20viral%20genome%20encodes%20a,makes%20them%20ideal%20therapeutic%20targets.\">Viral protease is responsible for the action<\/a> The protease is like a pair scissors in the hands and of a tailor. The protease is able to cut long-synthesized viral proteins (like a piece or cloth) into different fragments that have different functions. These protein fragments will be combined by the virus to form a virus particle.<\/p>\n<p>If the protease of a virus is blocked, the virus cannot replicate effectively.\u00a0<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2020.00215\/full\">As a therapeutic target, protease is often used.<\/a> By the pharmaceutical industry.<\/p>\n<p>The other active ingredient of\u00a0Paxlovid is an old HIV drug, ritonavir. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK544312\/#:~:text=Ritonavir%20is%20a%20protease%20inhibitor,also%20inhibits%20cytochrome%20P450%2D3A4.\">Ritonavir is an HIV protease inhibitor<\/a> that can help slow down the metabolism or <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9487421\/#CD015395-bbs2-0072\">breakdown of nirmatrelvir,<\/a> thus maintaining nirmatrelvir\u2019s effective concentrations.<\/p>\n<h2>1. Paxlovid Is Not Yet Approved by the FDA<\/h2>\n<p>On Dec. 22, 2021, the FDA issued an <a href=\"https:\/\/www.fda.gov\/media\/155049\/download\">Emergency Use Authorization (EUA) for Paxlovid<\/a> (nirmatrelvir tablets co-packaged with ritonavir tablets) to treat mild-to-moderate COVID-19.<\/p>\n<p>On June 30, 2022, Pfizer filed a New Drug Application (NDA) with the FDA, seeking approval for Paxlovid. As of today, however, it has not been approved by the FDA for the treatment of COVID-19.<\/p>\n<h2>2. Paxlovid Should Be Used Soon After Virus Infection<\/h2>\n<p>A group of researchers, mainly from Pfizer Worldwide Research, published an <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abl4784#F3\">article in Science<\/a> on Nov. 2, 2021, about the discovery and characterization of Paxlovid. In vitro antiviral activity of\u00a0Paxlovid has been evaluated in multiple cellular models. In vitro testing showed that\u00a0Paxlovid demonstrated potent antiviral activity against SARS-CoV-2, MERS-CoV, and other similar coronaviruses.<\/p>\n<p>However, the researchers noted that Paxlovid should be given very soon after a subject is infected with COVID-19.<\/p>\n<p>When given to\u00a0mice as early as four hours after infection with SARS-CoV-2, a 300 or 1,000 mg\/kg treatment of\u00a0Paxlovid was effective in reducing the SARS-CoV-2 viral load in the lungs.<\/p>\n<p>This means Paxlovid should be taken as early as possible post-virus infection. That is also the rationale for the inclusion criteria: only patients within five days of symptom onset were recruited in phase 2 and phase 3 clinical trials.\u00a0In other words, if the viral infection is in a late stage and the illness is more severe, Paxlovid may not be as helpful as it is for early infection.<\/p>\n<p>It is worth mentioning that the start time of giving Paxlovid treatment, four hours after the virus infected animals, was even shorter than another antiviral,\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41564-020-00835-2\">molnupiravir, which was dosed at 12 hours and 36 hours after virus infection in animals<\/a>.<\/p>\n<h2>3. Clinical Trial: 89 Percent Efficacy With Side Effects of Dysgeusia and Diarrhea<\/h2>\n<p><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/nejmoa2118542\">The findings<\/a> of phase 2\u20133 double-blind, randomized, controlled trial supported by Pfizer were published on Feb. 16, 2022, in the New England Journal of Medicine.<\/p>\n<p>The trial involved 2,246 symptomatic, unvaccinated, non-hospitalized adult patients who were at high risk for developing severe COVID-19 symptoms, and symptom onset was no more than five days. They were randomly selected to receive either Paxlovid 300 mg with other standard care or a placebo with other traditional medicine twice a day for five days.<\/p>\n<p>The final analysis, involving 1,379 patients, showed that Paxlovid reduced the risk of COVID-19-related hospitalization or death by 89 percent, compared to the placebo group when given less than five days after symptom onset.<\/p>\n<p>The main side effects observed with Paxlovid vs. control were dysgeusia (a taste disorder, 5.6 percent versus 0.3 percent) and diarrhea (3.1 percent versus 1.6 percent), both higher than the placebo group. This indicates potential side effects on the neurological and gastroenterological systems.<\/p>\n<p>Again, consistent with the development concept of this drug and aligned with its animal data, the drug has to be taken at an early stage of infection. Most patients (66.3 percent) received the first dose of the trial drug or placebo within three days after the onset of symptoms.<\/p>\n<p>In the real world, not many patients can take the drug in the first onset days, especially during the current Omicron era, as most patients may view their symptoms as a common cold and may not be aware of having contracted COVID-19.<\/p>\n<h2>4. Paxlovid Doesn\u2019t Work in Younger Patients<\/h2>\n<p>A large-scale observational, retrospective cohort <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2204919\">study involving more than 100,000 subjects<\/a>\u00a0conducted in Israel during the Omicron-surge phase was published in the New England Journal of Medicine on Sept. 1, 2022.<\/p>\n<p>This study was based on data obtained from a large health care organization covering approximately 52 percent of the Israeli population.<\/p>\n<p>The research took place while the Omicron variant was dominant; the study period started on Jan. 9, 2022, and <span>ended on March 31, 2022.<\/span><\/p>\n<figure id=\"attachment_5040772\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2023\/02\/PAXLOVID-Israel-Real-Life-Study.jpeg\"><img loading=\"lazy\" decoding=\"async\" class=\"lazy wp-image-5040772\" src=\"https:\/\/www.theepochtimes.com\/assets\/themes\/eet\/images\/white.png\" data-src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2023\/02\/PAXLOVID-Israel-Real-Life-Study.jpeg\" alt=\"Epoch Times Photo\" width=\"359\" height=\"483\"   style=\"display:none\"><figcaption class=\"wp-caption-text\"><noscript><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-5040772\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2023\/02\/PAXLOVID-Israel-Real-Life-Study.jpeg\" alt=\"Epoch Times Photo\" width=\"359\" height=\"483\" \/><\/noscript><\/figcaption><\/a> Cumulative Hazard Ratio for hospitalization due to Covid-19, according to age group and treatment status. (New England Journal of Medicine)<\/figure>\n<p>Researchers found that among patients 65 years of age or older, Paxlovid can lower the risk of hospitalization by 73 percent, and reduce the risk of death by 79 percent.\u00a0There was, however, no evidence of a benefit found in 40- to 64-year-old adults.<\/p>\n<h2>5. Finding \u201cTreatable\u201d Patients Has Proven Challenging<\/h2>\n<p>We may wonder why\u00a0Paxlovid works in elderly patients but not in the younger group of people in the Israel study.<\/p>\n<p>Paxlovid\u00a0has a narrow treatment window (five days after symptom onset) and a relatively short treatment period (five days only).\u00a0Phase 2 and 3 trials are conducted in a selected group of patients in a controlled study setting. However, real-life studies may not be able to replicate the same criteria as phase 2 and phase 3 trials do\u2014all this results in\u00a0<a href=\"https:\/\/www.fda.gov\/media\/155049\/download\">limitations for the clinical application of\u00a0Paxlovid and mixed efficacy data<\/a>.<\/p>\n<p>First, the drug has to be taken by a patient as early as possible after SARS-CoV-2 infection. This is based on a list of factors involving the drug\u2019s mechanism of action, development concept, preclinical study dosing timing, and the phase 3 study design. It\u2019s also common sense that earlier treatment offers a better outcome.<\/p>\n<p>However, it has been reported\u00a0<span>by a <a href=\"https:\/\/www.acpjournals.org\/doi\/10.7326\/M20-1495\">Johns Hopkins study<\/a>\u00a0that the \u201cgold standard\u201d COVID-19 PCR test has false negative rates ranging from 20 to 66 percent. <\/span>The false negative rate of the SARS-CoV-2 PCR test is much higher during earlier infection days than later.\u00a0<span>It can be up to 100 percent on the first day and down to 20 percent on the eighth day of exposure (typically the third day of symptoms).<\/span><\/p>\n<p>A <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0242958\">systematic review<\/a> of 34 studies enrolling 12,057 COVID-19-confirmed cases revealed that\u00a0up to 54 percent of COVID-19 patients might have an initial false-negative RT-PCR result.<\/p>\n<p>This results in a dilemma: on the one hand, we have to start treatment. On the other, the high false-negative rate hampers early Paxlovid application in the maximal patient population.<\/p>\n<p>Paxlovid is not indicated for treating COVID-19 patients who require hospitalization due to severe or critical COVID-19 diseases. Based on previous clinical trial data, none of those trials were conducted in severe COVID-19 patients, so it is essential to bear this point in mind.<\/p>\n<p>Furthermore, Paxlovid is not indicated for mild-to-moderate COVID-19 patients. Patients must present a\u00a0<a href=\"https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/need-extra-precautions\/people-with-medical-conditions.html\">high risk of progressing to severe diseases<\/a>, including but not limited to older age, underlying medical conditions of cancer, diabetes, chronic lung diseases, or chronic kidney diseases.<\/p>\n<p>Additional data support its use past five consecutive days. These factors together indicate that finding suitable test subjects has proven difficult.<\/p>\n<h2>6. In a Real-World Study, Paxlovid Has Shown Limited Effectiveness<\/h2>\n<p>In October 2022, Hong Kong University researchers compared the clinical effectiveness of two oral antiviral drugs, Paxlovid and molnupiravir, among Hong Kong residents. The researchers\u2019\u00a0<a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(22)01586-0\/fulltext\">observational study<\/a> was published in The Lancet.<\/p>\n<p>Between Feb. 26 and Jun. 26, 2022, among the 1,074,856 non-hospitalized patients infected with Omicron, 6,464 were treated with Paxlovid and 5,383 with molnupiravir.\u00a0Compared to the Paxlovid group, the molnupiravir group consisted of older and more unvaccinated patients.<\/p>\n<p>It is worth noting that these two antivirals were not compared directly in this study, but each was compared to its control group with matching patient conditions.<\/p>\n<p>Paxlovid reduced the mortality rate by 66 percent versus the control, while molnupiravir lowered the mortality rate by 24 percent versus its own control.<\/p>\n<p>Molnupiravir did not lower hospitalization rate, while Paxlovid lowered the hospitalization rate by 24 percent.<\/p>\n<p>Molnupiravir lowered in-hospital disease progression by 43 percent, while Paxlovid also decreased it by 43 percent.<\/p>\n<p>None of these rates look as good as Paxlovid\u2019s phase 2 and phase 3 clinical trial data. One of the most likely reasons is how well the narrow treatment window of the drug\u00a0has been followed, i.e., only five days after symptom onset.<\/p>\n<figure id=\"attachment_5033341\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2023\/02\/Hong-Kong-Study-Paxlovid-vs-Molnupiravir.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"lazy wp-image-5033341\" src=\"https:\/\/www.theepochtimes.com\/assets\/themes\/eet\/images\/white.png\" data-src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2023\/02\/Hong-Kong-Study-Paxlovid-vs-Molnupiravir.jpg\" alt=\"Epoch Times Photo\" width=\"702\" height=\"472\" \/><figcaption class=\"wp-caption-text\"><noscript><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-5033341\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2023\/02\/Hong-Kong-Study-Paxlovid-vs-Molnupiravir.jpg\" alt=\"Epoch Times Photo\" width=\"702\" height=\"472\" \/><\/noscript><\/figcaption><\/a> Hong Kong study results on the effectiveness of Paxlovid and molnupiravir. (The Epoch Times)<\/figure>\n<h2>7. Drug Resistance Is a Major Concern<\/h2>\n<p>Antiviral treatments are often associated with the development of drug-resistant viruses. There is a well-known saying in the antiviral community: \u201cNo antiviral, no resistance.\u201d<\/p>\n<p>A virus is a cunning microorganism. When you add pressure to its replication cycle, a virus will typically find a way to detour by mutating and will manage to survive. This is the primary mechanism of antiviral resistance.<\/p>\n<p>There are already quite a few lab research studies indicating SARS-CoV-2 could mutate to bypass the drug target, i.e., reducing the efficacy of the drug in actual clinical usage, as reported by <a href=\"https:\/\/www.science.org\/content\/article\/bad-news-paxlovid-coronavirus-can-find-multiple-ways-evade-covid-19-drug\">Science in June 2022<\/a>.<\/p>\n<p>In this sense, Paxlovid\u00a0is no different than other antivirals.<\/p>\n<p>Even though researchers reported that <a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(22)00412-4\/fulltext\">nirmatrelvir remained effective in multiple variants of SARS-CoV-2<\/a>, including Alpha, Beta, Delta, Gamma, Lambda, and Omicron, as well as the original strain, this does not mean that the drug will be effective against future variants of the virus.<\/p>\n<p>Two research groups have independently\u00a0shown that SARS-coV-2 quickly gains the ability to avoid nirmatrelvir\u2019s attack.<\/p>\n<p><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.06.07.495116v2\">One study was led by virologist Dirk Jochmans from Belgium<\/a>, who found that after a dozen rounds of nirmatrelvir treatment, SARS-CoV-2 developed three mutations\u2014at positions 50, 166, and 167 of the critical protease Mpro\u2014that reduced the virus\u2019 susceptibility to nirmatrelvir 20-fold.<\/p>\n<p>Judith Margarete Gottwein led the other study<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.06.06.494921v1\">\u00a0<\/a>at the University of Copenhagen. She spotted resistance-conferring mutations at similar positions 50 and 166 in Mpro, conferring 80-fold reduced susceptibility to nirmatrelvir.<span>\u00a0<\/span><\/p>\n<p>What\u2019s more shocking is the fact that two of the mutations (166 and 167) flagged by the Belgian group <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.05.27.493798v1\">were already reported to be circulating in people<\/a> according to a preprint\u00a0of research findings by United States scientists posted on May 30, 2022.<span>\u00a0<\/span><\/p>\n<p>As a result of this concern, patients under the use of Paxlovid should be regularly monitored for antiviral resistance, especially when signs of rebound\u00a0or reinfection appear.<\/p>\n<h2>8. Another Major Concern Is Paxlovid\u2019s Interaction With Other Drugs<\/h2>\n<p>CYP3A breaks down Paxlovid.\u00a0CYP3A is one of the <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9131486\/#:~:text=Abstract,numerous%20clinically%20useful%20therapeutic%20agents.\">most important enzymes<\/a> in our liver and digestive tract, which play a significant role in breaking down the drug.<\/p>\n<p>Potent CYP3A inducers will reduce the drug exposure of Paxlovid, resulting in loss of response to Paxlovid treatment and increased risks of drug resistance.<\/p>\n<p>Paxlovid is contraindicated with a long list of drugs of CYP3A inducers, partially due to the concern<span> of <span><span>potential<\/span>\u00a0<\/span>antivi<\/span>ral resistance.<\/p>\n<p>CYP3A inducers include\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cyp3a#:~:text=CYP3A%20inducers%20include%20the%20glucocorticoids,ketoconazole%2C%20clarithromycin%2C%20and%20verapamil.\">glucocorticoids, rifampin, carbamazepine, phenobarbital, and phenytoin<\/a>. A list of contraindicated drugs is available <a href=\"https:\/\/www.fda.gov\/media\/155050\/download\">here<\/a>. Patients must be made aware of these potentially risky interactions before they take Paxlovid.<\/p>\n<h2>9. Natural Immunity Influences the Success of Paxlovid and Other Antivirals<\/h2>\n<p>Even though we <span>applaud<\/span> the efforts by the pharma industry to develop antivirals, we should not forget those limitations. Furthermore, a well-functioning immune system is necessary for an antiviral drug to exert its effect.<\/p>\n<p>The main merit of antiviral drugs is that when the body\u2019s immune system is not strong enough, external drugs can temporarily inhibit the replication of the virus, giving our natural defense system some time to recover to its full strength.<\/p>\n<p>Meanwhile, we should not neglect the ability of our bodies to produce antiviral substances. Interferon, for example, is produced by many immune cells (white blood cells, NK, NKT, and T cells). As the name implies, through \u201cinterference,\u201d it achieves antiviral effects. Interferon is like a commander, giving instructions to coordinate various cells and signaling pathways to work together to fight a virus.<\/p>\n<p>There are <a href=\"https:\/\/www.theepochtimes.com\/health\/why-some-people-never-become-infected-with-covid-19_4999931.html\">many ways<\/a> to strengthen the amount and maximize the potential of the natural antiviral substances that our bodies make.<\/p>\n<figure class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"lazy\" src=\"https:\/\/www.theepochtimes.com\/assets\/themes\/eet\/images\/white.png\" data-src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2023\/02\/How-interferons-kill-the-virus.jpg\" alt=\"Epoch Times Photo\" width=\"683\" height=\"433\" \/><figcaption class=\"wp-caption-text\"><noscript><img loading=\"lazy\" decoding=\"async\" class=\"\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2023\/02\/How-interferons-kill-the-virus.jpg\" alt=\"Epoch Times Photo\" width=\"683\" height=\"433\" \/><\/noscript> Interferons interfere with the replication of the virus. (The Epoch Times)<\/figcaption><\/figure>\n<p>Natural immunity is an endogenous antiviral force in our body, like a joint force ready to fight against invading pathogens. If we are mindful enough to nourish our immunity in peaceful times, the defense mechanisms will work well when the \u201cwar\u201d comes.<\/p>\n<p>In summary, we should calmly view the strengths and limitations of antiviral drugs. On the one hand, we expect antiviral drugs to work well; on the other hand, we must enhance our immune system\u2019s power to resist the virus in a more natural, systematic, dynamic, and resourceful manner.<\/p>\n<p><i>Epoch Health articles are for informational purposes and are not a substitute for individualized medical advice. Please consult a trusted professional for personal medical advice, diagnoses, and treatment. Have a question? Email us at <a href=\"mailto:HealthReporter@epochtimes.nyc\">HealthReporter@epochtimes.nyc<\/a><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Are you able to tell when Paxlovid Should be used to treat COVID-19? Is it possible to see the differences between the clinical trial data of its phase 2 or 3 clinical trials and the real-life results? Are you aware of the main concern with Paxlovid for its future treatment of COVID-19 Reported to be &hellip;<\/p>\n","protected":false},"author":1,"featured_media":1841920,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mo_disable_npp":"","fifu_image_url":"https:\/\/cndimages.nyc3.digitaloceanspaces.com\/breaking-news\/wp-content\/uploads\/2021\/01\/IMG_2758-scaled-1.jpg","fifu_image_alt":"","footnotes":""},"categories":[547],"tags":[11716],"class_list":["post-1841917","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-the-bongino-report","tag-paxlovid"],"fifu_image_url":"https:\/\/cndimages.nyc3.digitaloceanspaces.com\/breaking-news\/wp-content\/uploads\/2021\/01\/IMG_2758-scaled-1.jpg","_links":{"self":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/1841917","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/comments?post=1841917"}],"version-history":[{"count":0,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/1841917\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media\/1841920"}],"wp:attachment":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media?parent=1841917"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/categories?post=1841917"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/tags?post=1841917"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}