{"id":1836568,"date":"2023-02-06T10:05:42","date_gmt":"2023-02-06T15:05:42","guid":{"rendered":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=1836568"},"modified":"2023-02-06T10:09:23","modified_gmt":"2023-02-06T15:09:23","slug":"immune-exhaustion-emerges-after-3rd-vaccine-dose-current-findings","status":"publish","type":"post","link":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/immune-exhaustion-emerges-after-3rd-vaccine-dose-current-findings\/","title":{"rendered":"Immune Exhaustion Emerges After 3rd Vaccine Dose: Current Findings"},"content":{"rendered":"<aside class=\"mashsb-container mashsb-main mashsb-stretched\"><div class=\"mashsb-box\"><div class=\"mashsb-count mash-medium\" style=\"float:left\"><div class=\"counts mashsbcount\">18<\/div><span class=\"mashsb-sharetext\">SHARES<\/span><\/div><div class=\"mashsb-buttons\"><a class=\"mashicon-facebook mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/www.facebook.com\/sharer.php?u=https%3A%2F%2Fwww.conservativenewsdaily.net%2Fbreaking-news%2Fimmune-exhaustion-emerges-after-3rd-vaccine-dose-current-findings%2F\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Facebook<\/span><\/a><a class=\"mashicon-twitter mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/twitter.com\/intent\/tweet?text=&amp;url=https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=1836568&amp;via=ConservNewsDly\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Twitter<\/span><\/a><a class=\"mashicon-subscribe mash-medium mash-nomargin mashsb-noshadow\" href=\"#\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Subscribe<\/span><\/a><div class=\"onoffswitch2 mash-medium mashsb-noshadow\" style=\"display:none\"><\/div><\/div>\n            <\/div>\n                <div style=\"clear:both\"><\/div><\/aside>\n            <!-- Share buttons by mashshare.net - Version: 4.0.47-->\n<p>Vaccines have been upheld as the best strategy for dealing with infectious diseases, but that\u2019s largely because of a limited understanding of the immune system and how to best complement and support its function. Although our bodies are able to distinguish the wheat from the chaff when infected pathogens are present or vaccines stimulate an immune response, there are many factors that could compromise this ability.<\/p>\n<p><a href=\"https:\/\/www.science.org\/doi\/epdf\/10.1126\/sciimmunol.ade2798\">A\u00a0study<\/a>\u00a0Published in Science Immunology <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36548397\/\">January 2023 <\/a>Based on the way they train our immune systems, incremental doses (first submitted August 2022) may prove to be one of these factors. In this instance, the immune response seemed to feel falsely secure after receiving the booster vaccine. The booster vaccine is supposed teach the immune systems how to fight the virus. Unfortunately, in this case, it seemed that the immune system has learned that it doesn\u2019t need to mount a strong counterattack. Worse, vaccine boosters may not have any effect on people at high risk for severe infection.<\/p>\n<h2>IgG Subtype Composition After Vaccination<\/h2>\n<p>According to the study, the third dose of the mRNA vaccines seems to be\u00a0linked with a class switch in subtypes of immunoglobulin G (IgG), the dominating serum antibody in our immune system, which raises the question of immune exhaustion.\u00a0A class switch is when B cells redirect their efforts to producing IgG. They produce IgM and generic immunoglobulin cells to start. They then switch to IgG to fight the infection once they realize the pathogen has become more difficult than they expected.<\/p>\n<p>IgG is a crucial serum antibody and makes up around 80 percent of all antibodies in the immune system. When class switching happens, B cells will release different types IgG in place of less effective immunoglobulin cells. The IgG ratio may vary depending on how severe the infection is.<\/p>\n<p>IgG, which is a more powerful fighter in our immune system&#8217;s defenses, has the ability to opsonize complements. It attaches to pathogens and infected cells, and instructs killer cell to swallow them through phagocytosis. It\u2019s also the only antibody that crosses into the placenta, playing a critical role in protecting the unborn fetus.<\/p>\n<figure id=\"attachment_5010685\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/img.theepochtimes.com\/assets\/uploads\/2023\/01\/25\/1-1200x744.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"lazy size-medium wp-image-5010685\" src=\"https:\/\/www.theepochtimes.com\/assets\/themes\/eet\/images\/white.png\" data-src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2023\/02\/1-600x372-1.jpg\" alt=\"Epoch Times Photo\" width=\"600\" height=\"372\"   style=\"display:none\"><figcaption class=\"wp-caption-text\"><noscript><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-5010685\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2023\/02\/1-600x372-1.jpg\" alt=\"Epoch Times Photo\" width=\"600\" height=\"372\" \/><\/noscript><\/figcaption><\/a> It is crucial for our health that IgG plays a critical role in our immune system. (The Epoch Times).<\/figure>\n<p>However, IgG is split up into four major subtypes\u2014denoted IgG1 through IgG4\u2014and each has its own strengths and limitations.<\/p>\n<p>IgG1 accounts for the majority of serum IgG. This is because it has the highest immune properties. These two IgG members are also the most potent.<\/p>\n<p>IgG4 is considered one of the weakest types, as it doesn\u2019t do as well in attracting immune cells responsible for eliminating invaders.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4202688\/\">Research shows<\/a> The IgG4 content is usually around 4 percent. This number was confirmed by the study on patients who received the second dose of vaccine after five months.<\/p>\n<p>Right after the second dose, IgG4 levels were at 0.04 percent while IgG1 and IgG3\u2014the most potent members in the IgG family\u2014made up 96.55 percent of all IgG, according to the aforementioned\u00a0Science Immunology paper.<\/p>\n<p>The body interprets this second dose of vaccine as a serious infection, and will produce the most effective IgG to fight the simulated infection. Things look slightly different after the booster shot.<\/p>\n<p>In the study, the percentage of IgG4 in the blood serum\u00a0rose to unexpectedly high levels after the third dose. IgG4 levels reached 13.91 percent ten days after the last vaccination and then rose to 19.27% five months later. IgG1 as well as IgG3 levels also dropped, which indicates a significant change of blood serum antibody composition.<\/p>\n<figure id=\"attachment_5010686\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/img.theepochtimes.com\/assets\/uploads\/2023\/01\/25\/2-1200x675.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"lazy size-medium wp-image-5010686\" src=\"https:\/\/www.theepochtimes.com\/assets\/themes\/eet\/images\/white.png\" data-src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2023\/02\/2-600x338-1.jpg\" alt=\"Epoch Times Photo\" width=\"600\" height=\"338\" \/><figcaption class=\"wp-caption-text\"><noscript><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-5010686\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2023\/02\/2-600x338-1.jpg\" alt=\"Epoch Times Photo\" width=\"600\" height=\"338\" \/><\/noscript><\/figcaption><\/a> Data has shown that IgG subtypes undergo dramatic changes after the third administration of an mRNA vaccine. (The Epoch Times).<\/figure>\n<p>This isn\u2019t good, as higher levels of IgG4, without the ability to stimulate immune cells,\u00a0could indicate immune exhaustion. It\u2019s also an indication that the immune system intentionally dampened the response starting with the third dose of the vaccination.<\/p>\n<p>On the other hand, although\u00a0IgG3 and IgG1\u00a0contribute the most to immune mechanisms,\u00a0the downside is that they\u2019re costly to produce and can quickly wear out the body. In contrast, IgG4 isn\u2019t as effective but it\u2019s more economical to produce.<\/p>\n<p>Outside intruders are always a top priority for the immune system. However, efficiency must also be considered. The amount of each IgG type produced varies depending on the infection.<\/p>\n<p>Science Immunology found that high IgG4 levels even after the third dose indicate that the immune system has been worn down by the repeated vaccinations. The body reacts more to the third dose and uses the less effective IgG4 as a response.<\/p>\n<p>The development of IgG4 is more dangerous than usual and can pose a risk to people who come in contact with the true virus. COVID-19 can become a very serious disease for those with chronic conditions. The body will begin to treat the SARS\/CoV-2 vaccine as if it were a boy who is crying wolf. What if the real thing knocks at the door?<\/p>\n<p>The vaccine is meant to train the immune system\u2019s memory cells so that the next time something similar comes along, they know how to quickly defend the immune system. This process is called antibody acquisition. This study shows that COVID-19 is no longer considered a serious virus infection by the body after the booster shot. The boosters may not have any effect in certain people.<\/p>\n<h2>Rates of Antibody Acquisition \u2018Extremely Low\u2019 Study Show for Organ Transplant Recipients<\/h2>\n<p>One group of people who might\u00a0gain the least from vaccination seems to include those who are immunocompromised, such as organ transplant recipients\u2014people who regularly take immunosuppressants as a part of post-operational procedures.<\/p>\n<p>A <a href=\"https:\/\/www.nature.com\/articles\/s41598-022-10510-7\">Nature published a study<\/a> The results showed that the antibody acquisition rates for COVID-19 were high. \u201cextremely low\u201d In kidney transplant patients. This finding contradicts the purpose of the vaccine, as it\u2019s meant to induce antibody acquisition.<\/p>\n<figure id=\"attachment_5010687\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/img.theepochtimes.com\/assets\/uploads\/2023\/01\/25\/3-1200x709.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"lazy size-medium wp-image-5010687\" src=\"https:\/\/www.theepochtimes.com\/assets\/themes\/eet\/images\/white.png\" data-src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2023\/02\/3-600x354-1.jpg\" alt=\"Epoch Times Photo\" width=\"600\" height=\"354\" \/><figcaption class=\"wp-caption-text\"><noscript><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-5010687\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2023\/02\/3-600x354-1.jpg\" alt=\"Epoch Times Photo\" width=\"600\" height=\"354\" \/><\/noscript><\/figcaption><\/a> Patients with organ transplants have difficulty neutralizing antibodies from the third doses of the mRNA COVID-19 vaccinations. (The Epoch Times).<\/figure>\n<p>Similar reports have been reported elsewhere as well, especially with regard to the newer COVID-19 variants. An <a href=\"https:\/\/journals.lww.com\/transplantjournal\/Fulltext\/2022\/07000\/Antibody_Response_to_a_Fourth_Dose_of_SARS_CoV_2.31.aspx\">observational study<\/a>\u00a0claiming to be the largest when analyzing four-dose vaccinated organ transplant recipients shows that the mRNA vaccine booster demonstrates a \u201clack of formal\u00a0neutralization\u201d against \u201cvariants of concern including Omicron.\u201d<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9111417\/pdf\/main.pdf\">Data\u00a0published<\/a>\u00a0by Elsevier\u00a0also shows that antibody neutralization against the Omicron coronavirus variant has seen a 15- to 20-fold reduction when compared with the wild-type virus in transplant recipients. These findings are of grave concern.<\/p>\n<p>The U.S. Centers for Disease Control and Prevention <a href=\"https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/vaccines\/recommendations\/immuno.html\">still\u00a0recommends<\/a>\u00a0that immunocompromised people receive a COVID-19 vaccine, as well as get their vaccine boosters.<\/p>\n<p><a href=\"https:\/\/journals.lww.com\/transplantjournal\/Fulltext\/2022\/07000\/COVID_19_Clinical_Outcomes_in_Solid_Organ.34.aspx\">According to\u00a0data published<\/a> in the medical journal Transplantation, during the recent Omicron wave, although COVID-19 cases have increased for organ transplant recipients, the death rate of this population has dropped fivefold.<\/p>\n<figure id=\"attachment_5016555\" class=\"wp-caption alignnone\"><a href=\"https:\/\/img.theepochtimes.com\/assets\/uploads\/2023\/01\/27\/transplant-1200x731.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"lazy wp-image-5016555 size-medium\" src=\"https:\/\/www.theepochtimes.com\/assets\/themes\/eet\/images\/white.png\" data-src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2023\/02\/transplant-600x365-1.jpg\" alt=\"Epoch Times Photo\" width=\"600\" height=\"365\" \/><figcaption class=\"wp-caption-text\"><noscript><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-5016555 size-medium\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2023\/02\/transplant-600x365-1.jpg\" alt=\"Epoch Times Photo\" width=\"600\" height=\"365\" \/><\/noscript><\/figcaption><\/a> Organ transplant recipients see an uptick in cases yet a lowered mortality rate during the Omicron surge. (The Epoch Times)<\/figure>\n<p>However, is this reduction due to repeated vaccination or to the reduced pathogenicity of Omicron variants? Is it really effective to drive vaccination campaigns for the immunocompromised, based on the trifling level of antibody acquisition? Can the benefits of repetitive boosting outweigh the increased risk of side effects?<\/p>\n<p>It\u2019s really time to reconsider what place the COVID-19 vaccines should take. Are we underestimating the wisdom of our immune system? This stance is similar to that taken in a <a href=\"https:\/\/www.theepochtimes.com\/health\/allowing-negative-efficacy-vaccines-upends-pre-pandemic-vaccine-standards_4889548.html\">previous article that mentions<\/a> how \u201cnegative efficacy\u201d should have stopped vaccine recommendations in their tracks.<\/p>\n<p>Now, researchers are saying that vaccines, especially boosters, fail to have a significant effect on the immunocompromised\u2014the very group of people especially susceptible to severe disease and death. We need to stop placing the mRNA shots on a pedestal and consider all options in response to SARS-CoV-2, such as focusing on bolstering our natural immune system and holistic well-being.<\/p>\n<p><i>Views expressed in this article are the opinions of the author and do not necessarily reflect the views of The Epoch Times. Epoch Health welcomes professional discussion and friendly debate. To submit an opinion piece, please follow these guidelines and submit through <a href=\"https:\/\/www.theepochtimes.com\/submission-guidelines_4553495.html\" target=\"_blank\" rel=\"noopener\">our form here<\/a>.<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vaccines have been upheld as the best strategy for dealing with infectious diseases, but that\u2019s largely because of a limited understanding of the immune system and how to best complement and support its function. Although our bodies are able to distinguish the wheat from the chaff when infected pathogens are present or vaccines stimulate an &hellip;<\/p>\n","protected":false},"author":1,"featured_media":1836571,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mo_disable_npp":"","fifu_image_url":"https:\/\/cndimages.nyc3.digitaloceanspaces.com\/breaking-news\/wp-content\/uploads\/2021\/01\/IMG_2758-scaled-1.jpg","fifu_image_alt":"","footnotes":""},"categories":[547],"tags":[17777,7559,17778,5998,17776,6701,12374,3954],"class_list":["post-1836568","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-the-bongino-report","tag-3rd","tag-current","tag-dose","tag-emerges","tag-exhaustion","tag-findings","tag-immune","tag-vaccine"],"fifu_image_url":"https:\/\/cndimages.nyc3.digitaloceanspaces.com\/breaking-news\/wp-content\/uploads\/2021\/01\/IMG_2758-scaled-1.jpg","_links":{"self":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/1836568","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/comments?post=1836568"}],"version-history":[{"count":0,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/1836568\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media\/1836571"}],"wp:attachment":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media?parent=1836568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/categories?post=1836568"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/tags?post=1836568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}