{"id":1786740,"date":"2022-12-26T06:30:07","date_gmt":"2022-12-26T11:30:07","guid":{"rendered":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=1786740"},"modified":"2022-12-26T07:50:19","modified_gmt":"2022-12-26T12:50:19","slug":"ivermectin-is-safe-and-effective-the-evidence","status":"publish","type":"post","link":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/ivermectin-is-safe-and-effective-the-evidence\/","title":{"rendered":"Ivermectin Is Safe and Effective: The Evidence"},"content":{"rendered":"<aside class=\"mashsb-container mashsb-main mashsb-stretched\"><div class=\"mashsb-box\"><div class=\"mashsb-count mash-medium\" style=\"&quot;\"><div class=\"counts mashsbcount\">14<\/div><span class=\"mashsb-sharetext\">SHARES<\/span><\/div><div class=\"mashsb-buttons\"><a class=\"mashicon-facebook mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/www.facebook.com\/sharer.php?u=https%3A%2F%2Fwww.conservativenewsdaily.net%2Fbreaking-news%2Fivermectin-is-safe-and-effective-the-evidence%2F\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Facebook<\/span><\/a><a class=\"mashicon-twitter mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/twitter.com\/intent\/tweet?text=&amp;url=https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=1786740&amp;via=ConservNewsDly\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Twitter<\/span><\/a><a class=\"mashicon-subscribe mash-medium mash-nomargin mashsb-noshadow\" href=\"#\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Subscribe<\/span><\/a><div class=\"onoffswitch2 mash-medium mashsb-noshadow\" style=\"display:none\"><\/div><\/div>\n            <\/div>\n                <div style=\"clear:both\"><\/div><\/aside>\n            <!-- Share buttons by mashshare.net - Version: 4.0.47--><div dir=\"auto\">\n<p>Ivermectin is on the World Health Organization (WHO) List of Essential Medicines and is approved by the US Food and Drug Administration (FDA).\u00a0 This well-tolerated but potent anti-parasitic medicine has been prescribed billions of times in its 36-year history against a wide range of parasites. It is a drug in the avermectin family, so named because those compounds are produced by the soil organism\u00a0<em>Streptomyces avermitilis.<\/em>\u00a0\u00a0 It has also been studied and used against a wide range of viruses especially over the last decade, and there is evidence of potent antiviral effects against Influenza A and over a dozen other viruses tested. [309]\n<p>In a meta-analysis of 63 studies of ivermectin versus COVID-19 in humans, 100% of these have shown positive results.\u00a0 Studies were from all continents except Antarctica.\u00a0 Considered individually, 29 of those studies were found to be statistically significant regarding use of ivermectin alone.\u00a0\u00a0 Over the 63 studies in meta-analysis, pooled effects showed 69% improvement in early treatment, and prophylactic use showed 86% improvement.\u00a0\u00a0 Of those studies in the meta-analysis that were peer-reviewed, overall improvement in early treatment was found to be 70% (64% in randomized controlled trials), and 86% of those in which ivermectin was used prophylactically showed improvement (84% in randomized controlled trials).<\/p>\n<p>Mortality from COVID-19 over all time periods of delay in treatment was 76% improved over controls (69% in randomized controlled trials), whereas mortality was improved 84% in early treatment of COVID-19 (82% in randomized controlled trials).\u00a0 Forty studies were excluded from the meta-analysis for complicating factors or insufficient detail reported, and these also showed 100% positive results.<\/p>\n<p>It is estimated that the likelihood of an ineffective treatment showing such positive results as the above results in the 63 studies in the meta-analysis to date is exceedingly small.\u00a0\u00a0 That probability is estimated to be one in one trillion. [310]\u00a0 The overall results of the meta-analysis were not only found to be \u201coverwhelmingly positive,\u201d but also \u201cvery consistent, and very insensitive to potential selection criteria, effect extraction rules, and\/or bias evaluation.\u201d \u00a0\u00a0The data in the meta-analysis are as of date of this article, and are continually updated as new studies are reported.<\/p>\n<p>The first clinical trial of ivermectin in COVID-19 patients was an observational study in four Florida hospitals from March to May 2020.\u00a0 \u00a0\u00a0Even in patients with severe pulmonary involvement, mortality was 38.8% in the treatment group vs 80.7% in controls, and this group showed the strongest mortality difference from controls, which raised the possibility of ivermectin also being available as a salvage or rescue treatment. [311]\n<p>In a randomized controlled trial, patients given ivermectin were 8 times more likely to be medically released than those in the placebo group.\u00a0 This was even though the average age and number of comorbidities were later found to be somewhat higher in the experimental group than in the control group. [312]\n<p>The African continent has had remarkably low incidence of COVID-19, particularly equatorial African countries.\u00a0 It may be helpful to look at African countries where ivermectin has been used commonly for decades against the onchocerciasis that it has been prescribed for, to observe population-wide effects.\u00a0 In this population comparison, risk of COVID-19 death was found to be 88.2% lower and morbidity 85.7% lower in 31 countries where onchocerciasis is endemic and ivermectin is commonly used than in 22 countries where neither is the case, even though the latter group of countries has a higher life expectancy, 66 years vs 61 years. [313]\n<p>Ivermectin, for all its power against viruses, is among the safest of medicines that are in long-term and widespread use. [314]\u00a0 There are no known serious drug-related adverse events. [315] Again, it is commonly taken by the populations of 31 African countries for effect against endemic parasites.\u00a0 Dosing has been given as a single annual dose of 150 mcg\/kg against filariasis.\u00a0 There have been very few serious adverse events reported over more than 30 years of use.\u00a0 37 of approximately 14,000 patients treated in Ghana had symptomatic posture hypotension, associated with fainting or sweating or tachycardia.\u00a0 These were treated with corticosteroids. [316]\u00a0 This Lancet study determined its safety in pregnant women, and the risk of fetal damage was not greater than in control women\u2019s fetuses. [317]\n<p>However, despite this safety data going back 3 decades, the US FDA has alleged, \u201cAny use of ivermectin for the prevention or treatment of COVID-19 should be avoided as its benefits and safety for these purposes have not been established.\u201d\u00a0 The FDA offered no supporting evidence for their claim. [318]\u00a0\u00a0 One concerning risk is that ivermectin is sold over the counter for veterinary use, and if people feel desperate to use it to ward off COVID-19, they might break off too large a piece from a large horse pill.\u00a0 For this reason, it is much better to consult a healthcare provider for ivermectin use and dosing.\u00a0 To further enhance safety, liposomal ivermectin carriers have been developed.\u00a0 When these were used against Dengue fever, cytotoxicity was reduced up to 5 times, absorption was faster and\u00a0<em>in vivo<\/em>\u00a0efficacy was improved. [319]\n<p>Despite the spectacular worldwide effect profile, of excellent effect against COVID-19, with 0.26% observed minor side effects, and its use across several continents, ivermectin is widely shunned and ignored in western Europe and in the US.\u00a0\u00a0\u00a0 Here is a brief synopsis of how that came to be.<\/p>\n<p>Ivermectin was invented in Japan in 1975 as an anti-parasitic drug by Satoshi Omura, a Kitasato University professor emeritus, which earned Dr. Omura the Nobel Prize in Biochemistry.\u00a0\u00a0 Ivermectin turned out to be quite effective against a broad spectrum of parasites. The drug was so effective in eliminating a range of parasitic infections, and at very low cost, about $0.10 US, that 3.7 billion doses have been delivered to much of the world\u2019s population since its invention. [320]\n<p>A cell culture study in April 2020 showed a 5000 times reduction in SARS-CoV-2 from one dose over 48 hours, compared to control samples. [321]\u00a0 Several Latin American countries, Egypt and India soon began to use it for COVID-19, and then South Africa and several European countries as well.\u00a0 However, resistance remained strong in the US and western Europe, following the vocal disapproval of The World Health Organization (WHO), The US National Institutes of Health (NIH), the US Food and Drug Administration (FDA) and the European Medicine Agency (EMA).\u00a0 These agencies all expressed disapproval of ivermectin for use with COVID-19 patients.\u00a0 Even after more than 20 randomized controlled clinical trials showed promising effect without adverse reactions, many western countries have still not adopted its use.<\/p>\n<p>Caly, Druce, et al illustrate the IMP inhibition as follows:<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"lazy alignnone size-medium wp-image-4944965\" src=\"https:\/\/www.theepochtimes.com\/assets\/themes\/eet\/images\/white.png\" data-src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/12\/b613726b-e4fe-4835-8cad-200afe5ce093_1645x1140-600x416-1.jpeg\" alt=\"Epoch Times Photo\" width=\"600\" height=\"416\"   style=\"display:none\"><\/p>\n<p><noscript><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-4944965\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/12\/b613726b-e4fe-4835-8cad-200afe5ce093_1645x1140-600x416-1.jpeg\" alt=\"Epoch Times Photo\" width=\"600\" height=\"416\" \/><\/noscript><\/p>\n<p>Figure \u00a9 L Caly, J Druce, et al., Endnote 321<\/p>\n<p>Social media companies censored ivermectin research.\u00a0 Even when the WHO commissioned and reported a meta-analysis of ivermectin, it was censored by YouTube.\u00a0 Only negative commentaries were permitted in western media. [322]\n<p>How does ivermectin send SARS-CoV-2 to lockdown?\u00a0 There are a number of mechanisms by which components of SARS-CoV-2 need to stay mobile and active in order to replicate, and thus to spread throughout the human body.\u00a0 It turns out that ivermectin binds several of these, which inactivates the virus.\u00a0 Let\u2019s look at exactly what happens to bind or to lock down SARS-CoV-2.<\/p>\n<p>RNA-dependent RNA-polymerase (RdRp) is one of the main enzymes used by SARS-CoV-2 to achieve RNA replication.\u00a0 It is required for viral genome replication, and therefore it is helpful if a nutrient or drug can act on it as an obstacle in some way.\u00a0 173 drugs were tested in this study for their ability to bind RdRp (making it unavailable or inactive), including two examined in this book, hydroxychloroquine and vitamin C, although vitamin C was also found to have relatively high binding energy for RdRp in this study.\u00a0 Of all the drugs tested, ivermectin was found to bind RdRp with higher binding any energy than any other drug. [323]\n<p>One strategy against SARS-CoV-2, as well as other endemic and pandemic RNA viruses, has been to interfere with transport of viruses into a host cell\u2019s nucleus.\u00a0 Ivermectin has been shown to accomplish this by binding, destabilizing and inhibiting the protein IMP alpha\/beta1.\u00a0 When this protein is inhibited, viruses are unable to enter a cell\u2019s nucleus, and therefore unable to replicate.\u00a0 Decreased infection results.\u00a0 IMP alpha\/beta 1 has been inhibited in SARS-CoV-2 entry into nuclei by ivermectin. [324]\u00a0 Previously, it has been observed that ivermectin inhibited that same protein from entry of other RNA viruses, giving it a broad-spectrum antiviral effect. [325] [326] [327]\n<p>It turns out that ivermectin not only binds tightly to RdRp on SARSCoV-2, and IMP alpha\/beta1; it also strongly binds the spike protein on SARS-CoV-2.\u00a0 This particular spike protein is trimeric, meaning it has 3 subunits which vary in amino acid sequences or other ways.\u00a0 It was observed that ivermectin binds all three of the SARS-CoV-2 subunits, both the structural S2 subunit, as well as both of the two functional S1 subunits. [328]\u00a0 This binding of all 3 subunits of the trimeric spike protein may be considered a trifecta of fortunate results of ivermectin in favor of the human host and in opposition to the SARS-CoV-2 virus.<\/p>\n<p>Ivermectin has different mechanisms against parasites, already a miraculous healing drug for that use alone through much of the world\u2019s population.\u00a0 However, now that we learn of its tremendous effect in binding both RdRp and all three trimers of the spike protein of SARS-CoV-2, we are certainly fortunate to have this medicine in our arsenal against COVID-19.\u00a0 It is inexpensive, and full COVID-19 treatment of an individual, from first dose till last needed can be less than one US dollar.\u00a0 Ivermectin is therefore available to even the poorest communities in the world.\u00a0 Ivermectin is being compared to the discovery of penicillin in its enormous impact, and perhaps was one of the greatest discoveries of the 20th century. [329]\u00a0 The fact that this tremendously effective, safe and low-cost antiviral drug is not as thoroughly known to the world as penicillin is a chasm of inexcusable and deadly ignorance that the COVID era is giving the world an opportunity to correct.<\/p>\n<\/div>\n<div dir=\"auto\">\n<p>309 K Sharun, K Dhama, et al.\u00a0 Ivermectin, a new candidate therapeutic against SARS-CoV-2\/COVID-19. May 30 2020. Ann Clin Microbiol Antimicrob.\u00a0 19 (23).\u00a0\u00a0<a href=\"https:\/\/ann-clinmicrob.biomedcentral.com\/articles\/10.1186\/s12941-020-00368-w\" rel=\"\">https:\/\/annclinmicrob.biomedcentral.com\/articles\/10.1186\/s12941-020-00368-w<\/a><\/p>\n<p>310\u00a0 Covid Analysis.\u00a0 Ivermectin is effective for COVID-19: Real-time meta-analysis of 49 studies.\u00a0 Nov 26 2020.\u00a0 Updated Mar 31 2021.\u00a0\u00a0<a href=\"https:\/\/ivmmeta.com\/\" rel=\"\">https:\/\/ivmmeta.com\/<\/a><\/p>\n<p>311\u00a0 J Rajter, M Sherman, et al.\u00a0 Use of ivermectin is associated with lower mortality in hospitalized patients with coronavirus disease 2019:\u00a0 The ivermectin in COVID nineteen study.\u00a0 Jan 2021.\u00a0 Chest.\u00a0 159 (1).\u00a0 85-92.\u00a0\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0012369220348984\" rel=\"\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0012369220348984<\/a><\/p>\n<p>312\u00a0 R Chahla, L Ruiz, et al.\u00a0 Ivermectin repurposing for COVID-19 treatment of outpatients in mild stage in primary health care centers.\u00a0 Mar 30 2021.\u00a0 MedRxiv.\u00a0\u00a0<a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2021.03.29.21254554v1\" rel=\"\">https:\/\/www.medrxiv.org\/content\/10.1101\/2021.03.29.21254554v1<\/a><\/p>\n<p>313\u00a0 H Tanioka, S Tanioka, et al.\u00a0 Why COVID-19 is not so spread in Africa: How does Ivermectin affect it?\u00a0 Mar 26 2021.\u00a0 MedRXiv.\u00a0\u00a0<a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2021.03.26.21254377v1.full-text\" rel=\"\">https:\/\/www.medrxiv.org\/content\/10.1101\/2021.03.26.21254377v1.full-text<\/a><\/p>\n<p>314\u00a0 T Jabeen, M Khader, et al.\u00a0 A review on the anti-parasitic drug ivermectin for various viral infections and possibilities of using it for novel severe acute respiratory syndrome coronavirus 2: New hope to treat coronavirus disease \u2013 2019.\u00a0 Jun 2020.\u00a0 Asian J Pharm Clin Res.\u00a0\u00a0<a href=\"https:\/\/www.researchgate.net\/publication\/343742900_A_REVIEW_ON_THE_ANTIPARASITIC_DRUG_IVERMECTIN_FOR_VARIOUS_VIRAL_INFECTIONS_AND_POSSIBILITIES_OF_USING_IT_FOR_NOVEL_SEVERE_ACUTE_RESPIRATORY_SYNDROME_CORONAVIRUS_2_NEW_HOPE_TO_TREAT_CORONAVIRUS_DISEASE\" rel=\"\">https:\/\/www.researchgate.net\/publication\/343742900_A_REVIEW_ON_THE _ANTIPARASITIC_DRUG_IVERMECTIN_FOR_VARIOUS_VIRAL_INFECTIONS_AND_POSSIBILITIES_OF_USING_IT_FOR_NOVEL_SEVERE_ACUTE_RESPIRATORY_SYNDROME_CORONAVIRUS_2_NEW_HOPE_TO_TREAT_CORONAVIRUS_DI SEASE<\/a><\/p>\n<p>315\u00a0 J Sanz-Navarro, C Feal, et al.\u00a0 Treatment of human scabies with oral ivermectin.\u00a0 Sep 2017.\u00a0 Actas Dermos.\u00a0 108 (7).\u00a0 643-649.\u00a0\u00a0\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28385424\/\" rel=\"\">https:\/\/pubmed.ncbi.nlm.nih.gov\/28385424\/<\/a><\/p>\n<p>316\u00a0 J Remme, R Baker, et al.\u00a0 A community trial of ivermectin in the onchocerciasis focus of Asubende, Ghana.\u00a0 I:\u00a0 Effect on the microfilarial reservoir and the transmission of Onchocerca volvulus.\u00a0 Sep 1989.\u00a0 Trop Med Parasitol.\u00a0 40 (3).\u00a0 367-374.\u00a0\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2617046\/\" rel=\"\">https:\/\/pubmed.ncbi.nlm.nih.gov\/2617046\/<\/a><\/p>\n<p>317\u00a0 M Pacqu\u00e9, B Mu\u00f1oz, et al.\u00a0 Pregnancy outcome after inadvertent ivermectin treatment during community-based distribution.\u00a0 Dec 15 1990.\u00a0 Lancet.\u00a0 336 (8729).\u00a0 1486-1489.\u00a0\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1979100\/\" rel=\"\">https:\/\/pubmed.ncbi.nlm.nih.gov\/1979100\/<\/a><\/p>\n<p>318\u00a0 US FDA.\u00a0 FAQ: COVID-19 and ivermectin intended for animals.\u00a0 Dec 16 2020.\u00a0<a href=\"https:\/\/www.fda.gov\/animal-veterinary\/product-safety-information\/faq-covid-19-and-ivermectin-intended-animals\" rel=\"\">https:\/\/www.fda.gov\/animal-veterinary\/product-safetyinformation\/faq-covid-19-and-ivermectin-intended-animals<\/a><\/p>\n<p>319\u00a0\u00a0R Croci, E Bottaro, et al.\u00a0 Liposomal systems as nanocarriers for the antiviral agent ivermectin.\u00a0 May 8 2016.\u00a0 Int J Biomater.\u00a0\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4875998\/\" rel=\"\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4875998\/<\/a><\/p>\n<p>320\u00a0\u00a0M Yagisawa, P Foster, et al.\u00a0 Global trends in clinical studies of ivermectin in COVID-19.\u00a0 Mar 10 2021.\u00a0 Japanese J Antibiotics.\u00a0 74 (1). \u00a044-95.\u00a0\u00a0<a href=\"http:\/\/jja-contents.wdc-jp.com\/pdf\/JJA74\/74-1-open\/74-1_44-95.pdf\" rel=\"\">http:\/\/jjacontents.wdc-jp.com\/pdf\/JJA74\/74-1-open\/74-1_44-95.pdf<\/a><\/p>\n<p>321\u00a0\u00a0L Caly, J Druce, et al.\u00a0 The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Jun 2020.\u00a0 Antiviral Res.\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0166354220302011?via%3Dihub\" rel=\"\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0166354220302011?via%3Dihub<\/a><\/p>\n<p>322\u00a0\u00a0M Turkia.\u00a0 A timeline of ivermectin-related events in the COVID-19 pandemic.\u00a0 Mar 2021.\u00a0\u00a0<a href=\"https:\/\/www.researchgate.net\/publication\/350496335_A_Timeline_of_Ivermectin-Related_Events_in_the_COVID-19_Pandemic\" rel=\"\">https:\/\/www.researchgate.net\/publication\/350496335_A_Timeline_of_Iver mectin-Related_Events_in_the_COVID-19_Pandemic<\/a><\/p>\n<p>323\u00a0\u00a0I Udofia, K Gbayo, et al.\u00a0 In silico studies of selected multi-drug targeting against 3CLpro and nsp12 RNA-dependent RNA-polymerase proteins of SARS-CoV-2 and SARS-CoV.\u00a0 Mar 25 2021.\u00a0 Network Mod Anal Health Inf Bioinf.\u00a0 10 (22).\u00a0\u00a0<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s13721-021-00299-2\" rel=\"\">https:\/\/link.springer.com\/article\/10.1007\/s13721-02100299-2<\/a><\/p>\n<p>324\u00a0\u00a0L Caly, J Druce, et al.\u00a0 The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Jun 2020.\u00a0 Antiviral Res.\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0166354220302011?via%3Dihub\" rel=\"\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0166354220302011?via%3Dihub<\/a><\/p>\n<p>325\u00a0\u00a0M Tay, J Fraser, et al.\u00a0 Nuclear localization of dengue (DENV) 1-4 nonstructural protein 5; protection against all 4 DENV serotypes by the inhibitor ivermectin.\u00a0 Sep 2013.\u00a0 Antivir Res.\u00a0 99 (3). 301-306.\u00a0\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0166354213001599\" rel=\"\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0166354213001599<\/a><\/p>\n<p>326\u00a0\u00a0\u00a0K Wagstaff, H Sivakumaran, et al.\u00a0 Ivermectin is a specific inhibitor of importin alpha\/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus. May 1 2012.\u00a0 J Biochem.\u00a0 443 (3).\u00a0\u00a0 851-856.\u00a0\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3327999\/\" rel=\"\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3327999\/<\/a><\/p>\n<p>327\u00a0\u00a0\u00a0S Yang, S Atkinson, et al.\u00a0 The broad spectrum antiviral ivermectin targets the host nuclear transport importin alpha\/beta1 heterodimer. May 2020.\u00a0 Antivir Res.\u00a0 104760.\u00a0\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0166354219307211\" rel=\"\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0166354219307211<\/a><\/p>\n<p>328 A Choudhury, N Das, et al.\u00a0 Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach.\u00a0 Future Vir.\u00a0 Mar 25 2021.\u00a0\u00a0<a href=\"https:\/\/www.futuremedicine.com\/doi\/10.2217\/fvl-2020-0342\" rel=\"\">https:\/\/www.futuremedicine.com\/doi\/10.2217\/fvl-2020-0342<\/a><\/p>\n<p>329 M Yagisawa, P Foster, et al.\u00a0 Global trends in clinical studies of ivermectin in COVID-19.\u00a0 Mar 10 2021.\u00a0 Japanese J Antibiotics.\u00a0 74 (1).\u00a0 44-95.\u00a0\u00a0<a href=\"http:\/\/jja-contents.wdc-jp.com\/pdf\/JJA74\/74-1-open\/74-1_44-95.pdf\" rel=\"\">http:\/\/jjacontents.wdc-jp.com\/pdf\/JJA74\/74-1-open\/74-1_44-95.pdf<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Ivermectin is on the World Health Organization (WHO) List of Essential Medicines and is approved by the US Food and Drug Administration (FDA).\u00a0 This well-tolerated but potent anti-parasitic medicine has been prescribed billions of times in its 36-year history against a wide range of parasites. It is a drug in the avermectin family, so named &hellip;<\/p>\n","protected":false},"author":1,"featured_media":1786743,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mo_disable_npp":"","fifu_image_url":"https:\/\/cndimages.nyc3.digitaloceanspaces.com\/breaking-news\/wp-content\/uploads\/2021\/01\/IMG_2758-scaled-1.jpg","fifu_image_alt":"","footnotes":""},"categories":[547],"tags":[6962,10847,5458,6051,4913,8467,3819,6551],"class_list":["post-1786740","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-the-bongino-report","tag-the","tag-and","tag-bongino","tag-effective","tag-evidence","tag-ivermectin","tag-report","tag-safe"],"fifu_image_url":"https:\/\/cndimages.nyc3.digitaloceanspaces.com\/breaking-news\/wp-content\/uploads\/2021\/01\/IMG_2758-scaled-1.jpg","_links":{"self":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/1786740","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/comments?post=1786740"}],"version-history":[{"count":0,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/1786740\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media\/1786743"}],"wp:attachment":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media?parent=1786740"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/categories?post=1786740"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/tags?post=1786740"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}