{"id":1645476,"date":"2022-09-17T08:57:49","date_gmt":"2022-09-17T12:57:49","guid":{"rendered":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=1645476"},"modified":"2022-09-17T09:00:07","modified_gmt":"2022-09-17T13:00:07","slug":"how-men-can-keep-estrogen-in-check","status":"publish","type":"post","link":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/how-men-can-keep-estrogen-in-check\/","title":{"rendered":"How Men Can Keep Estrogen in Check"},"content":{"rendered":"<aside class=\"mashsb-container mashsb-main mashsb-stretched\"><div class=\"mashsb-box\"><div class=\"mashsb-count mash-medium\" style=\"float:left\"><div class=\"counts mashsbcount\">14<\/div><span class=\"mashsb-sharetext\">SHARES<\/span><\/div><div class=\"mashsb-buttons\"><a class=\"mashicon-facebook mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/www.facebook.com\/sharer.php?u=https%3A%2F%2Fwww.conservativenewsdaily.net%2Fbreaking-news%2Fhow-men-can-keep-estrogen-in-check%2F\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Facebook<\/span><\/a><a class=\"mashicon-twitter mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/twitter.com\/intent\/tweet?text=&amp;url=https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=1645476&amp;via=ConservNewsDly\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Twitter<\/span><\/a><a class=\"mashicon-subscribe mash-medium mash-nomargin mashsb-noshadow\" href=\"#\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Subscribe<\/span><\/a><div class=\"onoffswitch2 mash-medium mashsb-noshadow\" style=\"display:none\"><\/div><\/div>\n            <\/div>\n                <div style=\"clear:both\"><\/div><\/aside>\n            <!-- Share buttons by mashshare.net - Version: 4.0.47--><div class=\"post\" itemprop=\"articleBody\">\n<div class=\"lightbox-wrapper\"><a class=\"lightbox\" href=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/e72dbe2fa7f4a96fcc6f65fc7cc066f73dead216.jpeg\" data-download-href=\"\/uploads\/short-url\/wZ6iyXjNHJ6kuFw0zEJwuxe9eg6.jpeg?dl=1\" title=\"Estrogen-Men\"><\/a><\/div>\n<h3>\nWhat All Men Need to Know<\/h3>\n<blockquote>\n<p>Men need it, but if you have too much your health risks skyrocket. Oh, and you\u2019ll be a pudgeball. Here\u2019s how to keep estrogen under control.<\/p>\n<\/blockquote>\n<h3>\nHigh Estrogen Leads To Degenerative Diseases, Early Death<\/h3>\n<p>Sometimes, doctors draw the wrong conclusion from a research study. Case in point, consider the big estrogen study reported in the Journal of the American Medical Association.<\/p>\n<p>Researchers monitored the estrogen levels of a large group of men. They found that men with estradiol (the most potent form of estrogen) in the normal range (between 21.80 and 30.11 pg\/ml) had the fewest deaths during a three-year period. Men with the highest levels (above 37.99) had 133 percent more deaths during the same time period. However, men with the lowest estrogen levels (below 12.90) fared the worst as they suffered 317 percent more deaths.<\/p>\n<p>Some doctors rightly concluded from this study that men need estrogen, but that\u2019s when they stopped thinking and went out to drive a few balls at the range.<\/p>\n<p>They figured that since men clearly need estrogen, they shouldn\u2019t do anything to reduce the estrogen levels of men with high estrogen. In other words, many doctors ignored the far more prevalent problem of high estrogen and, as such, are loathe to prescribe anti-estrogen medications.<\/p>\n<p>The problem is, once estrogen levels rise unchecked, bad things can happen.<\/p>\n<details>\n<summary>\nWhat Happens When Estrogen Levels Are Too High?<\/summary>\n<h3>\nWhat Happens When Estrogen Levels Are Too High?<\/h3>\n<p>When male estrogen levels are too high, the risk of degenerative disease skyrockets. Atherosclerosis rates go up. The incidence of stroke increases. The risk of developing Type II diabetes goes up. Emotional disturbances become more prevalent. The risk of prostate cancer increases, and erectile function suffers. Waistlines grow thicker. It becomes harder to put on muscle. And, most seriously, high estrogen significantly increases the risk of flat-out dying.<\/p>\n<p>Clearly, proper estrogen levels play a big part in the health of men\u2019s hearts, in addition to the health of a whole lot of body parts, body systems, and body functions. It\u2019s in every male\u2019s interest to make sure he\u2019s in an estrogen sweet spot, regardless of age.<\/p>\n<\/details>\n<details>\n<summary>\nThe Symptoms of High Estrogen<\/summary>\n<h3>\nThe Symptoms of High Estrogen<\/h3>\n<p>The average man, unaware of the true repercussions of having estrogen levels that are too high, might assume that symptoms include acting \u201cfeminine,\u201d sounding feminine, or developing skin as soft and supple as one of those expensive Japanese love dolls. None of that is true.<\/p>\n<p>For starters, high estrogen might make a man a little more emotional; perhaps prone to crying at the end of Hallmark Channel movies (or more prone to watching them in the first place), but it won\u2019t make them want to wear women\u2019s clothes, for Heaven\u2019s sake.<\/p>\n<p>Neither will it change a man\u2019s voice so that he sounds like Rueben, the busboy at Melvin\u2019s who has a voice like a nightingale. That\u2019s because the timbre and deepness of a man\u2019s voice is formed during puberty, and it isn\u2019t a two-way street \u2013 it can\u2019t reverse itself, regardless of the hormonal milieu.<\/p>\n<p>(That\u2019s also why, despite the miracles of modern surgery and endocrinology, a male transitioning to female will always be plagued by the voice they had before beginning medical procedures.)<\/p>\n<p>However, there are plenty of other real symptoms of high estrogen in males:<\/p>\n<ul>\n<li>Increased abdominal fat<\/li>\n<li>Loss of muscle mass<\/li>\n<li>Low libido, decreased erectile function<\/li>\n<li>Tiredness<\/li>\n<li>Increased fatty tissue around nipples<\/li>\n<li>Depression, emotional disturbances<\/li>\n<li>Lower urinary tract symptoms associated with benign prostatic hypertrophy (BPH)<\/li>\n<\/ul>\n<\/details>\n<details>\n<summary>\nWhat Causes High Estrogen?<\/summary>\n<h3>\nWhat Causes High Estrogen?<\/h3>\n<div class=\"lightbox-wrapper\"><a class=\"lightbox\" href=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/66c16950d3617aa458847207b95242c4cdbae2ee.jpeg\" data-download-href=\"\/uploads\/short-url\/eF15cO1yVICaPAIDuhxcDYuiCnQ.jpeg?dl=1\" title=\"Testosterone vs. Estrogen\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/66c16950d3617aa458847207b95242c4cdbae2ee_2_689x388.jpeg\" alt=\"Testosterone vs. Estrogen\" data-base62-sha1=\"eF15cO1yVICaPAIDuhxcDYuiCnQ\" width=\"689\" height=\"388\" srcset=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/66c16950d3617aa458847207b95242c4cdbae2ee_2_689x388.jpeg, https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/66c16950d3617aa458847207b95242c4cdbae2ee_2_1033x582.jpeg 1.5x, https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/66c16950d3617aa458847207b95242c4cdbae2ee.jpeg 2x\" data-small-upload=\"https:\/\/aws1.discourse-cdn.com\/tnation\/optimized\/4X\/6\/6\/c\/66c16950d3617aa458847207b95242c4cdbae2ee_2_10x10.png\" \/><\/a><\/div>\n<p>Testosterone gets most of the male press and estrogen gets most of the female press, but estrogen is, in many ways, just as important to men as testosterone. And, even though the two hormones are regarded as the yin and yang of human sexual behavior and development, molecularly they\u2019re very similar.<\/p>\n<p>You could even merge the two molecules into one three-dimensional figure and they\u2019d look identical, except that testosterone has one little extra carbon atom sticking straight up from its molecular bridgework. It\u2019s almost as if, appropriately, the testosterone molecule has its own little penis.<\/p>\n<p>And in this similarity lies one broad reason why some men have high estrogen levels. Since the testosterone molecule is so molecularly similar to estrogen, it\u2019s very easy for aromatase enzymes to Lorena-Bobbitt that one extra carbon atom off and convert testosterone to its counterpart.<\/p>\n<p>That\u2019s actually a good thing because, as explained, you need a certain level of estrogen. Not only does estrogen have innumerable effects on one\u2019s health, but it\u2019s also part of an elegant feedback system where overly high estrogen levels alert the testicles, via the pituitary, to send some testicular workers home and cut back on testosterone production for that day.<\/p>\n<p>In this way, the system keeps a perfect amount of testosterone and estrogen flowing through the body.<\/p>\n<p>Sometimes, though, too much testosterone is converted into estrogen. That amount, combined with the small amounts of estrogen being produced in the testes, adrenals, brain, and fat, can create a hormonal maelstrom of trouble. The feedback loop gets a kink in it. Estrogen levels stay perpetually high and thus keep barking the order to back off on the manufacture of testosterone.<\/p>\n<p>But there are plenty of other ways estrogen levels can get too high, too, and even though it\u2019s more uncommon and rarely discussed, low estrogen can be even more of a problem than high estrogen (signaling cardiovascular disease, autoimmune conditions, hypogonadism, etc.). Either way, though, estrogen levels need to be in the hormonal Goldilocks zone \u2013 not too high, not too low, but just right.<\/p>\n<\/details>\n<details>\n<summary>\nWhat Causes High Estrogen in Men?<\/summary>\n<h3>\nWhat Causes High Estrogen in Men?<\/h3>\n<p>Following are several reasons why you might have high-serum estrogen levels:<\/p>\n<h4>\n1. TOO MUCH BODY FAT<\/h4>\n<p>Fat contains the testosterone-to-estrogen changing aromatase enzyme, so as you get fatter you convert more testosterone to estrogen, which makes you even fatter. This peculiar bit of fat chemistry is like a fat snake trying to swallow its fat tail, and the only way you can get the snake to puke up its tail is to get lean and stay lean.<\/p>\n<h4>\n2. GETTING OLD<\/h4>\n<p>The older you are, the more aromatase you produce and the higher your estrogen levels. That\u2019s why old guys at the beach sometimes have decidedly non-perky breasts indistinguishable from those of their old wives.<\/p>\n<p>Of course, the age and estrogen thing isn\u2019t so cut and dried. Since levels of SHBG \u2013 a \u201cbinding\u201d hormone \u2013 also rise with age, presumably tying up some of the excess estrogen, you\u2019d think geezers would have less estrogen. Similarly, aging also generally brings a reduction in testosterone, which would mean there\u2019s less estrogen because there are fewer raw materials to convert to estrogen.<\/p>\n<p>Either way, it\u2019s somewhat of a mystery.<\/p>\n<h4>\n3. FAULTY FEEDBACK MECHANISMS<\/h4>\n<p>When estrogen levels are too high, they signal the testicles, via the pituitary, to temporarily stop making testosterone. But if estrogen levels are perpetually high, it can short-circuit the system, sending the mistaken message to the testicles to go on a long vacation to some testosterone-free land where they laze around all day listening to soft jazz. This can, in turn, lead to even higher estrogen levels.<\/p>\n<h4>\n4. TESTOSTERONE REPLACEMENT THERAPY (TRT)<\/h4>\n<p>Millions of men are on TRT to revitalize their bodies and shore up their flagging libidos. Unfortunately, a lot of doctors haven\u2019t done their homework. Injecting too much testosterone, or injecting too much testosterone into obese men, can cause an undesired amount of T to be converted into estrogen. These elevated levels need to be addressed by either adjusting the dosage or by prescribing an anti-aromatase (a drug that stops the conversion of T to E).<\/p>\n<h4>\n5. IMPAIRMENT OF CYTOCHROME P450 ENZYME SYSTEM<\/h4>\n<p>The P450 system is where most drugs go to die. In other words, most drugs, chemicals, or supplements you ingest are processed and eliminated by the P450 enzyme system. The system is like a chemical recycling station where drugs are torn down, repackaged, and either reused or excreted.<\/p>\n<p>This same system eliminates excess estrogen from the body, too. However, certain things can impair this system. Drinking too much might be a problem, as might being obese or having a <a href=\"https:\/\/www.t-nation.com\/supplements\/female-sex-drive-zinc-hormone-levels\/\">zinc deficiency<\/a>. You might also be eating foods or taking drugs or supplements that impede the P450 enzyme system\u2019s efficiency, like grapefruit juice or ginkgo biloba.<\/p>\n<h4>\n6. XENOESTROGENS<\/h4>\n<p>These are chemicals in the environment that mimic estrogen. These chemicals, mainly heavy metals, synthetic chemicals like DES and DDT, and industrial chemicals like phthalates, grow in number and accumulate in more tissue with each passing year.<\/p>\n<p>These chemicals are found in foods, adhesives, fire retardants, detergents, drinking water, perfumes, waxes, household cleaning products, lubricants\u2026 virtually everywhere.<\/p>\n<p>Although we don\u2019t know the exact scope of damage caused by these chemicals, we have seen widespread reports of biological anomalies in both animals and humans in the last couple of decades (mutations, indeterminate sex organs, lessened fertility, etc.).<\/p>\n<p>There\u2019s plenty of evidence that these chemicals are a part of all of us. Researchers found that 75% of the samples taken from 400 adults contained significant levels of industrial <a href=\"https:\/\/forums.t-nation.com\/t\/average-testosterone-levels-have-dropped-30\/\">xenoestrogens<\/a>, whereas 98.3 percent of samples contained DHT and its derivatives. To make matters even more troubling, different xenoestrogens appear to act synergistically so that their effects are magnified.<\/p>\n<h4>\n7. PHYTOESTROGENS<\/h4>\n<p>While xenoestrogens are man-made monstrosities, phytoestrogens occur in plants. Xenoestrogens accumulate in adipose tissue, while phytoestrogens are metabolized and booted out of the body relatively fast. As such, they\u2019re not nearly the problem that xenoestrogens are.<\/p>\n<p>Still, you generally don\u2019t want too many of them around as they resemble estrogen molecularly and can act like the real deal. Phytoestrogens are also found in various foods, perhaps most notably in soy products.<\/p>\n<h4>\n8. ALCOHOL AND WEED<\/h4>\n<p>Yeah, recreational drugs can cause elevated estrogen levels. Sorry.<\/p>\n<\/details>\n<details>\n<summary>\nWhat Are Normal Estrogen Levels?<\/summary>\n<h3>\nWhat Are Normal Estrogen Levels?<\/h3>\n<div class=\"lightbox-wrapper\"><a class=\"lightbox\" href=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/4adc9e1bc56c3edca5c0c152bd3cead5404f2ec5.jpeg\" data-download-href=\"\/uploads\/short-url\/aGg0eReyFmnx88JnYRU3drU0Vcp.jpeg?dl=1\" title=\"Estrogen Test\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/4adc9e1bc56c3edca5c0c152bd3cead5404f2ec5_2_689x388.jpeg\" alt=\"Estrogen Test\" data-base62-sha1=\"aGg0eReyFmnx88JnYRU3drU0Vcp\" width=\"689\" height=\"388\" srcset=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/4adc9e1bc56c3edca5c0c152bd3cead5404f2ec5_2_689x388.jpeg, https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/4adc9e1bc56c3edca5c0c152bd3cead5404f2ec5_2_1033x582.jpeg 1.5x, https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/4adc9e1bc56c3edca5c0c152bd3cead5404f2ec5.jpeg 2x\" data-small-upload=\"https:\/\/aws1.discourse-cdn.com\/tnation\/optimized\/4X\/4\/a\/d\/4adc9e1bc56c3edca5c0c152bd3cead5404f2ec5_2_10x10.png\" \/><\/a><\/div>\n<p>It\u2019s important that every man establish an estrogen baseline, to which he can refer to, compare, and maybe even brag about to his grandchildren in coming years. Here\u2019s a list of the median estradiol levels by age, as established by the authors of a study that appeared in the journal Clinical Endocrinology:<\/p>\n<ul>\n<li>Age 2-29: 28.0 pg\/ml<\/li>\n<li>Age 30-39: 25.7 pg\/ml<\/li>\n<li>Age 40-49: 24.7 pg\/ml<\/li>\n<li>Age 50-59: 22.1 pg\/ml<\/li>\n<li>Age 60-69: 21.5 pg\/ml<\/li>\n<li>Age 70-80: 21.9 pg\/ml<\/li>\n<\/ul>\n<p>Those values are considered optimal in approximately 95% of the male population; however, it\u2019s the rare individual who\u2019s going to hit his age-related bullseye with his estrogen levels. It\u2019s much more useful to say that normal ranges are from 10 to 30 or 40 picograms per milliliter for estrogen and 10 to 50 picograms per milliliter for estrone, a \u201cweaker\u201d type of estrogen.<\/p>\n<h4>\nHOW TO GET TESTED<\/h4>\n<p>There are pretty much only two ways to accurately test estrogen levels \u2013 via a 24-hour urine test or a blood test. The blood test is easier and less dangerously sloshy, of course, but if you go that route, make sure you insist that your doctor order a \u201csensitive\u201d assay.<\/p>\n<p>By default, most labs use the standard assay, which is designed for women. However, it\u2019s not good enough for males because their normal range is a lot smaller and more restrictive than for females.<\/p>\n<p>While I wrote above that the normal range for males is 10 to 40 picograms per ml, the normal range for women is 15 to 350 picograms per ml. They obviously have a lot more leeway; the test doesn\u2019t have to be as precise.<\/p>\n<p>That\u2019s not to say that high estrogen levels aren\u2019t problematic for women, too. They are. High estrogen can lead to some of the same medical problems in females as they can for men, in addition to fibrocystic lumps and irregular or heavy menstrual periods.<\/p>\n<p>But comparatively, what\u2019s considered a healthy estrogen range in a woman would likely cause a man to have some of the severe problems described above.<\/p>\n<p>Additionally, regarding the veracity of blood tests, most labs use immunoassay techniques to test blood samples, which, when compared to other methods, show a variability rate of up to 53%. That kind of inaccuracy could lead to a physician treating a problem that doesn\u2019t even exist, e.g., treating a man for high estrogen levels when he\u2019s well within normal ranges, which could lead to disastrous consequences.<\/p>\n<p>Labs should instead use Liquid Chromatography\/Mass Spectroscopy, which is much more accurate when measuring hormone levels. There are specific lab codes that your ordering doctor should use. If he doesn\u2019t use them or doesn\u2019t know them, tell him what they are:<\/p>\n<ul>\n<li>LabCorp \u201cSensitive Estradiol\u201d \u2013 Code 140244, 500108<\/li>\n<li>Quest Diagnostics \u201cUltrasensitive Estradiol\u201d \u2013 Code 30289<\/li>\n<li>Mayo Clinic \u201cEnhanced Estradiol\u201d \u2013 Code EEST<\/li>\n<\/ul>\n<\/details>\n<details>\n<summary>\nHow to Keep Estrogen in Check<\/summary>\n<h3>\nHow to Keep Estrogen in Check<\/h3>\n<p>Clearly, estrogen needs to be kept in check.<\/p>\n<p>Try to avoid xenoestrogens by reading labels or using \u201cnatural\u201d products around the home. Don\u2019t smoke too much weed, drink too much hootch, or get fat and\/or prematurely old if you can help it.<\/p>\n<p>And, if you still have symptoms, consider a natural estrogen-fighting supplement like <a href=\"https:\/\/biotest.t-nation.com\/products\/rez-v\">Rez-V\u2122<\/a> or, if the problem is severe, consult with a progressive doctor and get on an estrogen-lowering drug like Arimidex.<\/p>\n<p>However, before going the prescription route, make damn sure your levels are indeed high. The consequences are too severe to automatically assume you need treatment, as many doctors who prescribe testosterone replacement therapy routinely do.<\/p>\n<p><a href=\"https:\/\/biotest.t-nation.com\/products\/rez-v\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/025e17d2d148c563b5513d122bdd1fc76489c5f9.jpeg\" alt=\"Rez-V\" data-base62-sha1=\"kWy01vAo9R5nBQmd2LbGw8o48V\" width=\"500\" height=\"500\" \/><\/a><\/p>\n<\/details><\/div>\n<div class=\"post\" itemprop=\"articleBody\">\n<p>\u201cAtherosclerosis rates go up. The incidence of stroke increases.\u201d<\/p>\n<p>Link\/source of this? I\u2019ve read estrogen is protective agains atherosclerosis<\/p>\n<\/p><\/div>\n<div class=\"post\" itemprop=\"articleBody\">\n<p>Yes, when ranges are in the sweet spot. Too low or too high a problem:<\/p>\n<p>ivesten A, Hulthe J, Wallenfeldt K, et al. Circulating estradiol is an independent predictor of progression of carotid artery intima-media thickness in middle-aged men. J Clin Endocrinol Metab. 2006 Nov;91(11):4433-7. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16940451\/\" class=\"inline-onebox\">Circulating estradiol is an independent predictor of progression of carotid artery intima-media thickness in middle-aged men &#8211; PubMed<\/a><\/p>\n<p>Another:<\/p>\n<aside class=\"onebox allowlistedgeneric\" data-onebox-src=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/183891\">\n<header class=\"source\">\n      <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/aws1.discourse-cdn.com\/tnation\/original\/4X\/5\/a\/9\/5a9da70e205b090587a6584cc5e893fcc7eebccf.png\" class=\"site-icon\" width=\"48\" height=\"48\" alt=\"image\" \/><\/p>\n<p>      <a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/183891\" target=\"_blank\" rel=\"noopener\">jamanetwork.com<\/a><br \/>\n  <\/header>\n<article class=\"onebox-body\">\n<div class=\"aspect-image\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/ac72b28dde7bd275e033cd2fb62520c76a8db5dd_2_422x500.png\" class=\"thumbnail\" width=\"422\" height=\"500\" srcset=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/ac72b28dde7bd275e033cd2fb62520c76a8db5dd_2_422x500.png, https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/ac72b28dde7bd275e033cd2fb62520c76a8db5dd_2_633x750.png 1.5x, https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/ac72b28dde7bd275e033cd2fb62520c76a8db5dd_2_844x1000.png 2x\" data-small-upload=\"https:\/\/aws1.discourse-cdn.com\/tnation\/optimized\/4X\/a\/c\/7\/ac72b28dde7bd275e033cd2fb62520c76a8db5dd_2_10x10.png\" alt=\"image\" \/><\/div>\n<h3><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/183891\" target=\"_blank\" rel=\"noopener\">Circulating Estradiol and Mortality in Men With Systolic Chronic Heart Failure<\/a><\/h3>\n<p>Context\u00a0Androgen deficiency is common in men with chronic heart failure (HF) and is associated with increased morbidity and mortality. Estrogens are formed by the aromatization of androgens; therefore, abnormal estrogen metabolism would be&#8230;<\/p>\n<\/article>\n<\/aside>\n<p>There are probably better ones, but those are two I had at hand.<\/p>\n<\/p><\/div>\n<div class=\"post\" itemprop=\"articleBody\">\n<p>Thank you. This is good information that I haven\u2019t seen before. This study indicates the U shaped mortality curve in men with Heart Failure or LVEF. They admit that they don\u2019t know if High e2 is \u201crelated to critical body changes in the progression of HF or merely markers of that progression without a mechanistic role.\u201d<\/p>\n<p>Please let me know if you do find the article related specifically to Atherosclerosis, everything I can find shows estrogen is protective.<\/p>\n<p>This study in particular discusses atherosclerosis in men TREATED with Estrogen:<\/p>\n<p><a href=\"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.9.4.533\" rel=\"noopener nofollow ugc\"> https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.CIR.9.4.533<\/a><\/p>\n<p>VERY strong information in the discussion. Let me know what you think of it<\/p>\n<\/p><\/div>\n<div class=\"post\" itemprop=\"articleBody\">\n<aside class=\"quote no-group\" data-username=\"demonthrall\" data-post=\"4\" data-topic=\"279263\">\n<div class=\"title\">\n<p><img loading=\"lazy\" decoding=\"async\" alt=\"\" width=\"20\" height=\"20\" src=\"https:\/\/sea2.discourse-cdn.com\/tnation\/user_avatar\/forums.t-nation.com\/demonthrall\/40\/28004_2.png\" class=\"avatar\" \/> demonthrall:<\/div>\n<blockquote>\n<p>Please let me know if you do find the article related specifically to Atherosclerosis,<\/p>\n<\/blockquote>\n<\/aside>\n<p>This one talks about stroke risk, at least:<\/p>\n<aside class=\"onebox allowlistedgeneric\" data-onebox-src=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17310026\/\">\n<header class=\"source\">\n      <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/aws1.discourse-cdn.com\/tnation\/original\/4X\/0\/b\/2\/0b290a4921b8e2f10d94e55df2caf36eab63ad54.png\" class=\"site-icon\" width=\"64\" height=\"64\" alt=\"image\" \/><\/p>\n<p>      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17310026\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a><br \/>\n  <\/header>\n<article class=\"onebox-body\">\n    <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/3c1bbff0dafd3c031dfbbe19cfe16328fdaf8f55_2_500x500.png\" class=\"thumbnail onebox-avatar\" width=\"500\" height=\"500\" srcset=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/3c1bbff0dafd3c031dfbbe19cfe16328fdaf8f55_2_500x500.png, https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/3c1bbff0dafd3c031dfbbe19cfe16328fdaf8f55_2_750x750.png 1.5x, https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/3c1bbff0dafd3c031dfbbe19cfe16328fdaf8f55_2_1000x1000.png 2x\" data-small-upload=\"https:\/\/aws1.discourse-cdn.com\/tnation\/uploads\/default\/optimized\/4X\/3\/c\/1\/3c1bbff0dafd3c031dfbbe19cfe16328fdaf8f55_2_10x10.png\" alt=\"image\" \/><\/p>\n<h3><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17310026\/\" target=\"_blank\" rel=\"noopener\">Serum estradiol and risk of stroke in elderly men &#8211; PubMed<\/a><\/h3>\n<p>High levels of serum estradiol may be associated with an elevated risk of stroke in elderly men.<\/p>\n<\/article>\n<\/aside>\n<p>I\u2019ll look at the link you sent me when I get a chance. Thanks!<\/p>\n<\/p><\/div>\n<div class=\"post\" itemprop=\"articleBody\">\n<p>Gotta play organic chemist here:<\/p>\n<p>Your estrogen structure is incorrect.  You have a carbon with 5 bonds (the one holding the bolded extra carbon on the testosterone; the analogous spot on the estrogen does not have a group there at all).<\/p>\n<aside class=\"quote group-Verified\" data-username=\"TC_Luoma\" data-post=\"1\" data-topic=\"279263\">\n<div class=\"title\">\n<p><img loading=\"lazy\" decoding=\"async\" alt=\"\" width=\"20\" height=\"20\" src=\"https:\/\/sea2.discourse-cdn.com\/tnation\/user_avatar\/forums.t-nation.com\/tc_luoma\/40\/308079_2.png\" class=\"avatar\" \/> TC_Luoma:<\/div>\n<blockquote>\n<p>You could even merge the two molecules into one three-dimensional figure and they\u2019d look identical<\/p>\n<\/blockquote>\n<\/aside>\n<p>Not quite.  The estrogen has an aromatic group (the far six-membered carbon ring on the left) that is flat and planar.  The analogous region on the testosterone has saturated carbons (holding only single bonds) which are tetrahedral and not flat\/planar.  They cannot be superimposed.<\/p>\n<p>Okay, I\u2019ll go back to my day job now.<\/p>\n<\/p><\/div>\n<div class=\"post\" itemprop=\"articleBody\">\n<aside class=\"quote group-surge_challenge\" data-username=\"antiquity\" data-post=\"6\" data-topic=\"279263\">\n<div class=\"title\">\n<p><img loading=\"lazy\" decoding=\"async\" alt=\"\" width=\"20\" height=\"20\" src=\"https:\/\/sea2.discourse-cdn.com\/tnation\/user_avatar\/forums.t-nation.com\/antiquity\/40\/209079_2.png\" class=\"avatar\" \/> antiquity:<\/div>\n<blockquote>\n<p>Your estrogen structure is incorrect.<\/p>\n<\/blockquote>\n<\/aside>\n<p>Are you referring to the diagram? Let me go look at it. Thanks! And yes, I took some liberties with the &#8220;\u201cmerge\u201d thing; just trying to make a point. Their two dimensional structures are close, though.<\/p>\n<\/p><\/div>\n<div class=\"post\" itemprop=\"articleBody\">\n<aside class=\"quote group-surge_challenge\" data-username=\"antiquity\" data-post=\"6\" data-topic=\"279263\">\n<div class=\"title\">\n<p><img loading=\"lazy\" decoding=\"async\" alt=\"\" width=\"20\" height=\"20\" src=\"https:\/\/sea2.discourse-cdn.com\/tnation\/user_avatar\/forums.t-nation.com\/antiquity\/40\/209079_2.png\" class=\"avatar\" \/> antiquity:<\/div>\n<blockquote>\n<p>estrogen structure is incorrect<\/p>\n<\/blockquote>\n<\/aside>\n<p>To be picky\u2026<em>estradiol<\/em> structure.<\/p>\n<p>From above:<\/p>\n<div class=\"lightbox-wrapper\"><a class=\"lightbox\" href=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/78377a6b2838124898952c421dc0e2810a850c40.jpeg\" data-download-href=\"\/uploads\/short-url\/h9u9N8u7JnWq1riuTPiA8rsSwBq.jpeg?dl=1\" title=\"image\" rel=\"noopener nofollow ugc\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/78377a6b2838124898952c421dc0e2810a850c40_2_689x388.jpeg\" alt=\"image\" data-base62-sha1=\"h9u9N8u7JnWq1riuTPiA8rsSwBq\" width=\"689\" height=\"388\" srcset=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/78377a6b2838124898952c421dc0e2810a850c40_2_689x388.jpeg, https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/78377a6b2838124898952c421dc0e2810a850c40_2_1033x582.jpeg 1.5x, https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/78377a6b2838124898952c421dc0e2810a850c40.jpeg 2x\" data-small-upload=\"https:\/\/aws1.discourse-cdn.com\/tnation\/optimized\/4X\/7\/8\/3\/78377a6b2838124898952c421dc0e2810a850c40_2_10x10.png\" \/><\/a><\/div>\n<p>Steroid metabolic pathways:<\/p>\n<div class=\"lightbox-wrapper\"><a class=\"lightbox\" href=\"https:\/\/aws1.discourse-cdn.com\/tnation\/original\/4X\/7\/5\/0\/7502a57fecea380b3768710c2c0793f91a7ede07.jpeg\" data-download-href=\"\/uploads\/short-url\/gH7x76AqSCgDK7GxNDsNKuY574r.jpeg?dl=1\" title=\"image\" rel=\"noopener nofollow ugc\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/7502a57fecea380b3768710c2c0793f91a7ede07_2_563x500.jpeg\" alt=\"image\" data-base62-sha1=\"gH7x76AqSCgDK7GxNDsNKuY574r\" width=\"563\" height=\"500\" srcset=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/7502a57fecea380b3768710c2c0793f91a7ede07_2_563x500.jpeg, https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/7502a57fecea380b3768710c2c0793f91a7ede07_2_844x750.jpeg 1.5x, https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/7502a57fecea380b3768710c2c0793f91a7ede07_2_1126x1000.jpeg 2x\" data-small-upload=\"https:\/\/aws1.discourse-cdn.com\/tnation\/optimized\/4X\/7\/5\/0\/7502a57fecea380b3768710c2c0793f91a7ede07_2_10x10.png\" \/><\/a><\/div>\n<aside class=\"quote group-surge_challenge\" data-username=\"antiquity\" data-post=\"6\" data-topic=\"279263\">\n<div class=\"title\">\n<p><img loading=\"lazy\" decoding=\"async\" alt=\"\" width=\"20\" height=\"20\" src=\"https:\/\/sea2.discourse-cdn.com\/tnation\/user_avatar\/forums.t-nation.com\/antiquity\/40\/209079_2.png\" class=\"avatar\" \/> antiquity:<\/div>\n<blockquote>\n<p>bolded extra carbon<\/p>\n<\/blockquote>\n<\/aside>\n<p>Methyl group for the reader<\/p>\n<p>Nice clarifications.<\/p>\n<aside class=\"quote group-Verified\" data-username=\"TC_Luoma\" data-post=\"7\" data-topic=\"279263\">\n<div class=\"title\">\n<p><img loading=\"lazy\" decoding=\"async\" alt=\"\" width=\"20\" height=\"20\" src=\"https:\/\/sea2.discourse-cdn.com\/tnation\/user_avatar\/forums.t-nation.com\/tc_luoma\/40\/308079_2.png\" class=\"avatar\" \/> TC_Luoma:<\/div>\n<blockquote>\n<p>Their two dimensional structures are close, though.<\/p>\n<\/blockquote>\n<\/aside>\n<p>Haha.  Maybe for the casual <em>Breaking Bad<\/em> viewer.<\/p>\n<p>Thanks for the article TC.  I am waiting for the legion of Worldlink Medical people to swarm the site.  Watch your back <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/emoji.discourse-cdn.com\/apple\/rofl.png?v=12\" title=\":rofl:\" class=\"emoji\" alt=\":rofl:\" width=\"20\" height=\"20\" \/>.<\/p>\n<p>More info:<\/p>\n<aside class=\"onebox wikipedia\" data-onebox-src=\"https:\/\/en.m.wikipedia.org\/wiki\/Steroid\">\n<header class=\"source\">\n<p>      <a href=\"https:\/\/en.m.wikipedia.org\/wiki\/Steroid\" target=\"_blank\" rel=\"noopener nofollow ugc\">en.m.wikipedia.org<\/a><br \/>\n  <\/header>\n<article class=\"onebox-body\">\n<div class=\"aspect-image\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/aws1.discourse-cdn.com\/tnation\/original\/4X\/5\/7\/1\/571bcf914e23de849ebedfb5200d15b461f9f360.png\" class=\"thumbnail\" width=\"220\" height=\"168\" alt=\"image\" \/><\/div>\n<h3><a href=\"https:\/\/en.m.wikipedia.org\/wiki\/Steroid\" target=\"_blank\" rel=\"noopener nofollow ugc\">Steroid<\/a><\/h3>\n<p>\n A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and as signaling molecules. Hundreds of steroids are found in plants, animals and fungi. All steroids are manufactured in cells from the sterols lanosterol (opisthokonts) or cycloartenol (plants). Lanosterol and cycloartenol are derived from the cyclization of &#8230;<\/p>\n<\/article>\n<\/aside><\/div>\n<div class=\"post\" itemprop=\"articleBody\">\n<aside class=\"quote no-group\" data-username=\"readalot\" data-post=\"8\" data-topic=\"279263\">\n<div class=\"title\">\n<p><img loading=\"lazy\" decoding=\"async\" alt=\"\" width=\"20\" height=\"20\" src=\"https:\/\/sea2.discourse-cdn.com\/tnation\/user_avatar\/forums.t-nation.com\/readalot\/40\/274249_2.png\" class=\"avatar\" \/> readalot:<\/div>\n<blockquote>\n<p>Maybe for the casual <em>Breaking Bad<\/em> viewer.<\/p>\n<\/blockquote>\n<\/aside>\n<p>You dissin\u2019 Breaking Bad viewers? <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/emoji.discourse-cdn.com\/apple\/wink.png?v=12\" title=\":wink:\" class=\"emoji\" alt=\":wink:\" width=\"20\" height=\"20\" \/><br \/>Thanks for keeping us on our toes!<\/p>\n<\/p><\/div>\n<div class=\"post\" itemprop=\"articleBody\">\n<p>No way.  I enjoyed it.  Anything to improve science literacy <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/emoji.discourse-cdn.com\/apple\/joy.png?v=12\" title=\":joy:\" class=\"emoji\" alt=\":joy:\" width=\"20\" height=\"20\" \/>.<\/p>\n<p>And BTW\u2026where is <a class=\"mention\" href=\"https:\/\/forums.t-nation.com\/u\/andrewgen_receptors\">@Andrewgen_Receptors<\/a> to make a Worldlink Medical Meme when you need him?<\/p>\n<p><em>\u201cWhat you talking about TC?\u201d<\/em><\/p>\n<p>Headshot below.<\/p>\n<aside class=\"onebox allowlistedgeneric\" data-onebox-src=\"https:\/\/worldlinkmedical.com\/member\/neal-rouzier-md\/\">\n<header class=\"source\">\n      <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/aws1.discourse-cdn.com\/tnation\/original\/4X\/5\/a\/b\/5abaf07d07d8f0416f3554f71ba14c40e900d6e3.png\" class=\"site-icon\" width=\"32\" height=\"32\" alt=\"image\" \/><\/p>\n<p>      <a href=\"https:\/\/worldlinkmedical.com\/member\/neal-rouzier-md\/\" target=\"_blank\" rel=\"noopener nofollow ugc\">APIM<\/a><br \/>\n  <\/header>\n<article class=\"onebox-body\">\n    <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/09\/1373e3325000d427cad8ec4618d395052a4b89cc.jpeg\" class=\"thumbnail onebox-avatar\" width=\"365\" height=\"365\" alt=\"image\" \/><\/p>\n<h3><a href=\"https:\/\/worldlinkmedical.com\/member\/neal-rouzier-md\/\" target=\"_blank\" rel=\"noopener nofollow ugc\">Neal Rouzier, MD | APIM<\/a><\/h3>\n<\/article>\n<\/aside><\/div>\n<div class=\"post\" itemprop=\"articleBody\">\n<aside class=\"quote group-Verified\" data-username=\"TC_Luoma\" data-post=\"7\" data-topic=\"279263\">\n<div class=\"title\">\n<p><img loading=\"lazy\" decoding=\"async\" alt=\"\" width=\"20\" height=\"20\" src=\"https:\/\/sea2.discourse-cdn.com\/tnation\/user_avatar\/forums.t-nation.com\/tc_luoma\/40\/308079_2.png\" class=\"avatar\" \/> TC_Luoma:<\/div>\n<blockquote>\n<p>Are you referring to the diagram? Let me go look at it. Thanks! And yes, I took some liberties with the &#8220;\u201cmerge\u201d thing; just trying to make a point. Their two dimensional structures are close, though.<\/p>\n<\/blockquote>\n<\/aside>\n<p>Yes, I agree.  They are close in terms of the \u201cmerge\u201d, and I get your point.  I teach Organic Chemistry so I spot structural errors in ways that no one else here would care about.  <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/emoji.discourse-cdn.com\/apple\/grin.png?v=12\" title=\":grin:\" class=\"emoji\" alt=\":grin:\" width=\"20\" height=\"20\" \/><\/p>\n<p>I just excited to see skeletal structures of organic compounds!<\/p>\n<\/p><\/div>\n<div class=\"post\" itemprop=\"articleBody\">\n<p>TBH man, I know nothing of WorldLink Medical, so it makes it difficult to meme them.<\/p>\n<p>To quote the Magic 8-Ball \u201cBetter luck next time!\u201d<\/p>\n<\/p><\/div>\n<div class=\"post\" itemprop=\"articleBody\">\n<p>Hence the reference to them in this thread doesn\u2019t compute for you.  Gotcha.<\/p>\n<\/p><\/div>\n<div class=\"post\" itemprop=\"articleBody\">\n<p>Hi All, recently has my Oestradiol check, is this e2? This is a type of estrogen isnt it? My levels were 116, just says <150 so guess its in range but is this too high? Please let us know your thoughts><br \/>\n        <\/150><\/p>\n<\/div>\n<div class=\"post\" itemprop=\"articleBody\">\n<p>Hi there, just started using some supplements to help manage high E, always was a bit chubbier and kept fat on my lower back, hips, and chest. Actively losing weight now, and using zinc 50mg, vitamin e 800 UI, and grape seed extract 400mg. So far I think it might be working, as I feel drier, but it\u2019s only been a couple of days.<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>What All Men Need to Know Men need it, but if you have too much your health risks skyrocket. Oh, and you\u2019ll be a pudgeball. Here\u2019s<\/p>\n","protected":false},"author":1,"featured_media":1645478,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mo_disable_npp":"","fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[],"tags":[],"class_list":["post-1645476","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/1645476","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/comments?post=1645476"}],"version-history":[{"count":0,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/1645476\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media\/1645478"}],"wp:attachment":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media?parent=1645476"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/categories?post=1645476"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/tags?post=1645476"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}