{"id":1643403,"date":"2022-09-16T16:12:10","date_gmt":"2022-09-16T20:12:10","guid":{"rendered":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=1643403"},"modified":"2022-09-16T16:13:01","modified_gmt":"2022-09-16T20:13:01","slug":"exercise-hormone-stops-parkinsons-symptoms-in-mice","status":"publish","type":"post","link":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/exercise-hormone-stops-parkinsons-symptoms-in-mice\/","title":{"rendered":"Exercise Hormone Stops Parkinson\u2019s Symptoms in Mice"},"content":{"rendered":"<aside class=\"mashsb-container mashsb-main mashsb-stretched\"><div class=\"mashsb-box\"><div class=\"mashsb-count mash-medium\" style=\"float:left\"><div class=\"counts mashsbcount\">14<\/div><span class=\"mashsb-sharetext\">SHARES<\/span><\/div><div class=\"mashsb-buttons\"><a class=\"mashicon-facebook mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/www.facebook.com\/sharer.php?u=https%3A%2F%2Fwww.conservativenewsdaily.net%2Fbreaking-news%2Fexercise-hormone-stops-parkinsons-symptoms-in-mice%2F\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Facebook<\/span><\/a><a class=\"mashicon-twitter mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/twitter.com\/intent\/tweet?text=&amp;url=https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=1643403&amp;via=ConservNewsDly\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Twitter<\/span><\/a><a class=\"mashicon-subscribe mash-medium mash-nomargin mashsb-noshadow\" href=\"#\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Subscribe<\/span><\/a><div class=\"onoffswitch2 mash-medium mashsb-noshadow\" style=\"display:none\"><\/div><\/div>\n            <\/div>\n                <div style=\"clear:both\"><\/div><\/aside>\n            <!-- Share buttons by mashshare.net - Version: 4.0.47--><div><\/div>\n<p><em>A hormone secreted into the blood during endurance, or aerobic, exercise reduces levels of a protein linked to Parkinson\u2019s disease and halts movement problems in mice, researchers report.<\/em><\/p>\n<p>Parkinson\u2019s disease, a\u00a0<a href=\"https:\/\/www.futurity.org\/parkinsons-disease-skin-sample-test-2459902-2\/\">neurologic condition<\/a>\u00a0that causes people to lose control over their muscles and movements, affects about 1 million people in the US.<\/p>\n<p>If confirmed in additional laboratory research and clinical trials, the researchers\u2019 study in mice engineered to have Parkinson\u2019s disease symptoms could pave the way for a Parkinson\u2019s disease therapy based on the hormone irisin.<\/p>\n<p>Johns Hopkins Medicine\u2019s Ted Dawson, and the Dana Farber Cancer Institute\u2019s Bruce Spiegelman worked together to look into the link between the exercise molecule irisin and Parkinson\u2019s disease.<\/p>\n<p>For unknown reasons, endurance exercise has long been found to alleviate\u00a0<a href=\"https:\/\/www.futurity.org\/parkinsons-disease-zombie-neurons-2209622\/\">symptoms<\/a>\u00a0of Parkinson\u2019s disease. Dawson, whose research focuses on neurodegenerative diseases, including Parkinson\u2019s disease, says one of the first clues to the link between exercise, Parkinson\u2019s disease, and irisin came from Spiegelman, whose first paper about irisin was published in 2012 in\u00a0<em>Nature<\/em>\u00a0and subsequently in other scientific journals, showing that a protein called an irisin peptide is released into the blood and increases with endurance exercise.<\/p>\n<div class=\"pull-quote\">\n<p>If irisin\u2019s utility pans out, we could envision it being developed into a gene or recombinant protein therapy.<\/p>\n<\/div>\n<p>In the past decade, other laboratories have found that exercise elevates levels of irisin, and there is interest in looking into the connection between irisin and Alzheimer\u2019s disease as well as Parkinson\u2019s disease.<\/p>\n<p>To test the effects of irisin on Parkinson\u2019s disease, Dawson and Spiegelman\u2019s teams began with a research model used by Dawson in which mouse brain cells are engineered to spread small, spindly fibers of\u00a0<a href=\"https:\/\/www.futurity.org\/parkinsons-disease-voice-brains-2736182\/\">alpha synuclein<\/a>, a protein that regulates moods and movements related to the brain neurotransmitter dopamine.<\/p>\n<p>When alpha synuclein\u00a0<a href=\"https:\/\/www.futurity.org\/nanobody-brain-cells-proteins-2775332-2\/\">proteins clump<\/a>, those clusters kill dopamine-producing brain cells, a key trigger of Parkinson\u2019s disease. Fibrous clumps of alpha synuclein are very similar, says Dawson, to what is found in the brains of people with Parkinson\u2019s disease.<\/p>\n<p>In the laboratory model, the researchers found that irisin prevented the accumulation of alpha synuclein clumps and its associated brain cell death.<\/p>\n<p>Next, the research teams tested irisin\u2019s effects on mice engineered to have Parkinson\u2019s-like symptoms. They injected alpha synuclein into an area of the mouse brain, called the striatum, where dopamine-producing neurons extend. Two weeks later, the researchers injected a viral vector, which increased blood levels of irisin, which can cross the blood-brain barrier, into the mice.<\/p>\n<p>Six months later, mice that received irisin had no muscle movement deficits, while those injected with a placebo showed deficits in grip strength and their ability to descend a pole.<\/p>\n<p>The researchers demonstrated that irisin also speeds up the transport and degradation of alpha synuclein via fluid-filled sacs called lysosomes in brain cells.<\/p>\n<p>\u201cIf irisin\u2019s utility pans out, we could envision it being developed into a gene or recombinant protein therapy,\u201d says Dawson, referring to the widening field of drug development aimed at using cellular genetics to treat disease. Dawson is a professor in neurodegenerative diseases, a professor of neurology, and director of the Johns Hopkins Institute for Cell Engineering.<\/p>\n<p>\u201cGiven that irisin is a naturally produced peptide hormone and seems to have evolved to cross the blood brain-barrier, we think it is worth continuing to evaluate irisin as a potential therapy for Parkinson\u2019s and other forms of neurodegeneration\u201d adds Spiegelman.<\/p>\n<p>Dawson and Spiegelman have filed for patents on the use of irisin in Parkinson\u2019s disease. Spiegelman has created a biotechnology company, Aevum Therapeutics Inc., based in Boston, to develop irisin into treatments for neurodegenerative disease.<\/p>\n<p>Results of the researchers\u2019 tests appear in the\u00a0<em><a href=\"https:\/\/doi.org\/10.1073\/pnas.2204835119\">Proceedings of the National Academy of Sciences<\/a><\/em>.<\/p>\n<p>Additional scientists who contributed to the research are from Johns Hopkins and Harvard Medical School.<\/p>\n<p>Funding for the research came from the JPB Foundation, the Maryland Stem Cell Research Fund, the Mark Foundation for Cancer Research, the Damon Runyon Cancer Research Foundation, and Deutsche Forschungsgemeinschaft.<\/p>\n<p><em>This article was originally published by\u00a0<a href=\"https:\/\/www.hopkinsmedicine.org\/news\/newsroom\/news-releases\/exercise-hormone-halts-parkinsons-disease-symptoms-in-mouse-study\">Johns Hopkins University<\/a>. Republished via <a href=\"https:\/\/www.futurity.org\">Futurity.org<\/a> under Creative Commons License 4.0.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A hormone secreted into the blood during endurance, or aerobic, exercise reduces levels of a protein linked to Parkinson\u2019s disease and halts movement problems in mice, researchers report.Parkinson\u2019s disease, a\u00a0neurologic<\/p>\n","protected":false},"author":1,"featured_media":1643405,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mo_disable_npp":"","fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[],"tags":[],"class_list":["post-1643403","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/1643403","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/comments?post=1643403"}],"version-history":[{"count":0,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/1643403\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media\/1643405"}],"wp:attachment":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media?parent=1643403"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/categories?post=1643403"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/tags?post=1643403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}