{"id":1595897,"date":"2022-08-09T08:02:05","date_gmt":"2022-08-09T12:02:05","guid":{"rendered":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=1595897"},"modified":"2022-08-09T08:02:45","modified_gmt":"2022-08-09T12:02:45","slug":"broccoli-compound-may-solve-antibiotic-resistance-problem","status":"publish","type":"post","link":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/broccoli-compound-may-solve-antibiotic-resistance-problem\/","title":{"rendered":"Broccoli Compound May Solve Antibiotic Resistance Problem"},"content":{"rendered":"<aside class=\"mashsb-container mashsb-main mashsb-stretched\"><div class=\"mashsb-box\"><div class=\"mashsb-count mash-medium\" style=\"&quot;\"><div class=\"counts mashsbcount\">14<\/div><span class=\"mashsb-sharetext\">SHARES<\/span><\/div><div class=\"mashsb-buttons\"><a class=\"mashicon-facebook mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/www.facebook.com\/sharer.php?u=https%3A%2F%2Fwww.conservativenewsdaily.net%2Fbreaking-news%2Fbroccoli-compound-may-solve-antibiotic-resistance-problem%2F\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Facebook<\/span><\/a><a class=\"mashicon-twitter mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/twitter.com\/intent\/tweet?text=&amp;url=https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=1595897&amp;via=ConservNewsDly\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Twitter<\/span><\/a><a class=\"mashicon-subscribe mash-medium mash-nomargin mashsb-noshadow\" href=\"#\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Subscribe<\/span><\/a><div class=\"onoffswitch2 mash-medium mashsb-noshadow\" style=\"display:none\"><\/div><\/div>\n            <\/div>\n                <div style=\"clear:both\"><\/div><\/aside>\n            <!-- Share buttons by mashshare.net - Version: 4.0.47--><div><\/div>\n<p><em>Antimicrobial resistance has been on the rise for decades, making easily treatable infections a serious threat again. The breakthrough could lie in these everyday vegetables, which attack the killer cells responsible for one of the deadliest modern diseases.<\/em><\/p>\n<div id=\"bodytext\" data-swiftype-name=\"postbody\" data-swiftype-type=\"text\">\n<p>Cruciferous vegetables have long been cherished for their health benefits. Broccoli, cabbage, collards, Brussels sprouts, cauliflower, kale and bok choy, just to name a few, contain several plant compounds that are important for optimal health, including powerful chemoprotective compounds.<\/p>\n<p>One of the most well-known of these is sulforaphane, an organic sulfur. Studies have shown sulforaphane supports normal cell function and division while causing apoptosis (programmed cell death) in colon,<sup><span id=\"edn1\" data-hash=\"#ednref1\">1<\/span><\/sup>\u00a0liver,<sup><span id=\"edn2\" data-hash=\"#ednref2\">2<\/span><\/sup>\u00a0prostate,<sup><span id=\"edn3\" data-hash=\"#ednref3\">3<\/span><\/sup>\u00a0breast<sup><span id=\"edn4\" data-hash=\"#ednref4\">4<\/span><\/sup>\u00a0and tobacco-induced lung cancer.<sup><span id=\"edn5\" data-hash=\"#ednref5\">5<\/span><\/sup>\u00a0Just three servings of broccoli per week may reduce a man\u2019s risk of prostate cancer by more than 60%.<sup><span id=\"edn6\" data-hash=\"#ednref6\">6<\/span><\/sup><\/p>\n<p>Another important phytochemical found in cruciferous veggies is indole-3 carbinol (I3C),<sup><span id=\"edn7\" data-hash=\"#ednref7\">7<\/span><\/sup>\u00a0which in your gut is converted into diindolylmethane (DIM). DIM in turn boosts immune function and, like sulforaphane, plays a role in the prevention and treatment of cancer.<sup><span id=\"edn8\" data-hash=\"#ednref8\">8<\/span>,<span id=\"edn9\" data-hash=\"#ednref9\">9<\/span><\/sup><\/p>\n<h2>Cruciferous Compound Can Break Antibiotic Resistance<\/h2>\n<p>Interestingly, researchers now believe that DIM may be a potent weapon against antibiotic-resistant pathogens as well.<sup><span id=\"edn10\" data-hash=\"#ednref10\">10<\/span>,<span id=\"edn11\" data-hash=\"#ednref11\">11<\/span><\/sup>\u00a0Israel21c.org reports:<sup><span id=\"edn12\" data-hash=\"#ednref12\">12<\/span><\/sup><\/p>\n<blockquote>\n<p><em>\u201cA phytochemical derived from cruciferous vegetables, such as broccoli, breaks down the biofilm that lets bacteria resist antibiotics, according to a study from Ben-Gurion University in Israel \u2026 The paper,<sup><span id=\"edn13\" data-hash=\"#ednref13\">13<\/span><\/sup>\u00a0co-authored by researchers from Near East University and Girne American University in Cyprus, was published in the journal Pharmaceutics.<\/em><\/p>\n<\/blockquote>\n<p><em>The scientists found that phytochemical 3,3\u2032-diindolylmethane (DIM) successfully broke down the biofilms protecting pathogens including Acinetobacter baumannii and Pseudomonas aeruginosa 65% and 70% of the time, respectively \u2026<\/em><\/p>\n<blockquote>\n<p><em>When the team introduced DIM into an infected wound, it sped up the healing process significantly. \u2018Our findings show promise for other avenues of research in addition to known classes of antibiotics,\u2019 said [professor Ariel] Kushmaro.\u201d<\/em><\/p>\n<\/blockquote>\n<h2>Antibiotic Resistance Is a Serious Problem<\/h2>\n<p>This could potentially be the breakthrough we\u2019ve been searching for. Antimicrobial resistance has been on the rise for decades, thus making infections that were previously easy to treat a serious threat again. According to the World Health Organization, antimicrobial resistance is \u201cone of the top 10 global public health threats facing humanity,\u201d<sup><span id=\"edn14\" data-hash=\"#ednref14\">14<\/span><\/sup>\u00a0and the primary cause for this man-made epidemic is the widespread misuse of antibiotics.<\/p>\n<p>Antibiotic overuse occurs not just in human medicine, but also in food production. In fact, agricultural uses account for about 80% of all antibiotic use in the U.S.,<sup><span id=\"edn15\" data-hash=\"#ednref15\">15<\/span><\/sup>\u00a0so it\u2019s a major source of human antibiotic consumption.<\/p>\n<p>Animals are often fed antibiotics at low doses for disease prevention and growth promotion, and those antibiotics are transferred to you via meat and other animal products, and even via the manure used as crop fertilizer.<\/p>\n<p>DIM was able to inhibit biofilm formation in Acinetobacter baumannii and Pseudomonas aeruginosa by 65% to 70% respectively. When DIM was combined with the antibiotic tobramycin, biofilm growth of P. aeruginosa was diminished by 98%.\n<\/p>\n<p>Many pathogens have also developed resistance to more than one drug, so-called pan-resistance, which makes treating them even more problematic. And, while pan-resistant superbugs are increasing, the development of new antibiotics to tackle them has come to a near halt. According to the WHO:<sup><span id=\"edn16\" data-hash=\"#ednref16\">16<\/span><\/sup><\/p>\n<blockquote>\n<p><em>\u201cIn 2019 WHO identified 32 antibiotics in clinical development that address the WHO list of priority pathogens, of which only six were classified as innovative. Furthermore, a lack of access to quality antimicrobials remains a major issue. Antibiotic shortages are affecting countries of all levels of development and especially in health care systems.<\/em><\/p>\n<\/blockquote>\n<blockquote>\n<p><em>Antibiotics are becoming increasingly ineffective as drug-resistance spreads globally leading to more difficult to treat infections and death. New antibacterials are urgently needed \u2014 for example, to treat carbapenem-resistant gram-negative bacterial infections as identified in the WHO priority pathogen list.<\/em><\/p>\n<\/blockquote>\n<blockquote>\n<p><em>However, if people do not change the way antibiotics are used now, these new antibiotics will suffer the same fate as the current ones and become ineffective.\u201d<\/em><\/p>\n<\/blockquote>\n<h2>DIM for Pan-Resistant Bacteria<\/h2>\n<p>The four pathogenic bacteria investigated in the study<sup><span id=\"edn17\" data-hash=\"#ednref17\">17<\/span><\/sup>\u00a0cited above \u2014 Pseudomonas aeruginosa, Acinetobacter baumannii, Serratia marcescens and Providencia stuartii \u2014 are all gram-negative bacteria, and in the initial investigation, DIM reduced biofilm formation in all four by as much as 80%.<\/p>\n<p>Of these, Pseudomonas aeruginosa and Acinetobacter baumannii are both resistant to multiple drugs, so in follow-up tests they focused on these two specifically. As previously noted, DIM was able to inhibit biofilm formation in these bacteria by 65% to 70%. When DIM was combined with the antibiotic tobramycin, biofilm growth of P. aeruginosa was diminished by 98%.<\/p>\n<p>Nonhealing wounds are often infected with pan-resistant bacteria, and it\u2019s the biofilm that prevents the tissues from healing back together. To test whether DIM could work topically in these scenarios, the researchers infected puncture wounds on pigs with P. aeruginosa, and then applied a cream containing either DIM alone, the antibiotic gentamycin alone, or DIM plus gentamycin combined.<\/p>\n<p>Wounds treated with DIM for 10 days healed significantly better than untreated wounds, thanks to a significant reduction in biofilm formation, and the combination of DIM plus antibiotic worked even better. Wounds treated with gentamycin alone saw no improvement.<\/p>\n<h2>When to Use This Phytochemical<\/h2>\n<p>Just like high-dose vitamin C, which is another potent weapon to treat infections, especially when used IV, I don\u2019t believe that DIM should be used every day as a prophylactic to prevent infections. It should be used only when needed to treat antibiotic resistant infections as it will likely do so without any of the side effects of potent antibacterials.<\/p>\n<h2>Other Health Benefits of Cruciferous Vegetables<\/h2>\n<p>While you may not be able to treat a pan-resistant infection with a few servings of broccoli, the fact that this food may offer a solution to the pressing problem of antibiotic-resistance is exciting, and just goes to show that nature has answers to many of our problems \u2014 including problems we\u2019ve created ourselves.<\/p>\n<p>That said, cruciferous veggies have many other health benefits that are worth taking note of, and which you can obtain simply by including more of them in your diet. In addition to its anticancer benefits, I3C \u2014 the precursor to DIM \u2014 is also a powerful antioxidant, and can help balance both male and female hormones, thereby supporting reproductive health in both sexes.<\/p>\n<p>I3C also supports your liver\u2019s detoxification processes, and helps heal liver damage by supporting the reproduction of normal, healthy cells. Sulforaphane, meanwhile, has been shown to have antidiabetic properties and improves blood pressure.<sup><span id=\"edn18\" data-hash=\"#ednref18\">18<\/span><\/sup>\u00a0It also supports healthy kidney function<sup><span id=\"edn19\" data-hash=\"#ednref19\">19<\/span><\/sup>\u00a0and gut health<sup><span id=\"edn20\" data-hash=\"#ednref20\">20<\/span><\/sup>\u00a0by normalizing DNA methylation.<\/p>\n<p>In simple terms, DNA methylation<sup><span id=\"edn21\" data-hash=\"#ednref21\">21<\/span><\/sup>\u00a0is the process by which a methyl group (one carbon atom attached to three hydrogen atoms) is added to part of a DNA molecule. This is a crucial part of normal cell function as it allows cells to \u201cremember who they are and where they have been.\u201d DNA methylation also suppresses viral- and other disease-related gene expression.<\/p>\n<p>Just realize that broccoli is not a \u201cmagic\u201d bullet. In fact, some physicians, like Dr. Paul Saladino, present powerful arguments that nearly all vegetables are to be avoided (but not fruits). This is because the hormetic benefits from their phytochemicals can be obtained in other lifestyle measures.<\/p>\n<p>The most important lifestyle measure would be to avoid all seed oils. If you only limited your diet changes to keep your seed oil less than 2% of your daily calories as confirmed by Cronometer, I strongly believe your health would improve exponentially more than regularly having the finest organic\/biodynamic vegetables.<\/p>\n<p>This is largely because excess LA (linoleic acid) is the most pernicious toxin in our food supply and is responsible for most all of our chronic diseases. Other lifestyle measures to improve your health would include exercise, regular sun exposure on bare skin, and sauna. Having said that, compounds found in broccoli and other cruciferous veggies have been shown to:<\/p>\n<ul>\n<li><strong>Lower your risk of obesity<\/strong><sup><span id=\"edn22\" data-hash=\"#ednref22\">22<\/span><\/sup><\/li>\n<li><strong>Suppress inflammation \u2014<\/strong>\u00a0In part by reducing (by as much as 73%) reactive oxygen species that cause cell damage,<sup><span id=\"edn23\" data-hash=\"#ednref23\">23<\/span><\/sup>\u00a0and in part through the creation of short chain fatty acids (SCFAs).<sup><span id=\"edn24\" data-hash=\"#ednref24\">24<\/span><\/sup>\u00a0The fiber in cruciferous veggies is broken down into SCFAs by gut bacteria, and SCFAs have been shown to lessen your risk of inflammatory diseases<\/li>\n<li><strong>Improve Type 2 diabetes by reducing glucose production \u2014<\/strong>\u00a0In one study, patients with dysregulated diabetes who received broccoli sprout extract in addition to metformin had up to 10% lower fasting blood glucose levels than the placebo group.<sup><span id=\"edn25\" data-hash=\"#ednref25\">25<\/span><\/sup>\u00a0Sulforaphane also lowers your risk of other health problems associated with Type 2 diabetes, such as heart disease and stroke<\/li>\n<li><strong>Support healthy liver function and lower your risk of nonalcoholic fatty liver disease<\/strong><sup><span id=\"edn26\" data-hash=\"#ednref26\">26<\/span><\/sup><\/li>\n<li><strong>Reduce risk of osteoarthritis<\/strong><sup><span id=\"edn27\" data-hash=\"#ednref27\">27<\/span><\/sup>\u00a0<strong>\u2014<\/strong>\u00a0In part by blocking enzymes linked to joint destruction<sup><span id=\"edn28\" data-hash=\"#ednref28\">28<\/span><\/sup><\/li>\n<li><strong>Improve allergies and asthma<\/strong>\u00a0by reducing oxidative stress in your airways and countering cell damage caused by pollution and allergens<sup><span id=\"edn29\" data-hash=\"#ednref29\">29<\/span><\/sup><\/li>\n<li><strong>Improve verbal communication and decrease repetitive behaviors in children with autism \u2014<\/strong>\u00a0This effect is thought to be related to sulforaphane\u2019s ability to trigger a heat-shock response \u2014 a biological effect that protects cells from stress during a fever. Previous research has shown that, in some autistic people, repetitive behaviors decline during fevers.<\/li>\n<\/ul>\n<p>In one study, positive results from sulforaphane were observed within as little as four weeks. Communication improved, as did symptoms of hyperactivity and irritability. By the end of the 18-week study, about half (15 of 29) of those receiving sulforaphane experienced improved ability to interact socially<sup><span id=\"edn30\" data-hash=\"#ednref30\">30<\/span><\/sup><\/p>\n<ul>\n<li><strong>Improve chemically-induced colitis and leaky gut<\/strong><sup><span id=\"edn31\" data-hash=\"#ednref31\">31<\/span><\/sup><\/li>\n<li><strong>Inhibit Helicobacter pylori<\/strong>\u00a0(H. pylori), the bacteria thought to cause gastric ulcers<sup><span id=\"edn32\" data-hash=\"#ednref32\">32<\/span><\/sup><\/li>\n<li><strong>Increase your free testosterone level<\/strong><sup><span id=\"edn33\" data-hash=\"#ednref33\">33<\/span><\/sup><\/li>\n<li><strong>Protect muscles against exercise-induced damage<\/strong><sup><span id=\"edn34\" data-hash=\"#ednref34\">34<\/span><\/sup><\/li>\n<li><strong>Facilitate detoxification of chemical pollutants<\/strong><sup><span id=\"edn35\" data-hash=\"#ednref35\">35<\/span>,<span id=\"edn36\" data-hash=\"#ednref36\">36<\/span>,<span id=\"edn37\" data-hash=\"#ednref37\">37<\/span><\/sup><\/li>\n<li><strong>Protect against neurodegenerative diseases<\/strong>\u00a0such as Parkinson\u2019s and Alzheimer\u2019s disease<sup><span id=\"edn38\" data-hash=\"#ednref38\">38<\/span><\/sup><\/li>\n<li><strong>Promote healthy, beautiful skin<\/strong>\u00a0(a side effect of improved liver function and detox). Sulforaphane also helps protect your skin against damage from UV radiation<sup><span id=\"edn39\" data-hash=\"#ednref39\">39<\/span><\/sup><\/li>\n<\/ul>\n<\/div>\n<div data-swiftype-name=\"postbody\" data-swiftype-type=\"text\">\n<h2>How to Optimize the Benefits of Broccoli<\/h2>\n<p>To get the most out of your broccoli, lightly steam it for three to four minutes until it\u2019s tough-tender. Do not steam longer than five minutes. This will allow you to get the most bioavailable sulforaphane out of it. If you opt for boiling, blanch the broccoli in boiling water for no more than 20 to 30 seconds, then immerse it in cold water to stop the cooking process.<\/p>\n<p>If you want to augment the sulforaphane content even further, pair broccoli and other cruciferous veggies with a myrosinase-containing food<sup><span id=\"edn40\" data-hash=\"#ednref40\">40<\/span><\/sup>\u00a0such as mustard seed,<sup><span id=\"edn41\" data-hash=\"#ednref41\">41<\/span><\/sup>\u00a0daikon radishes, wasabi, arugula or coleslaw. Of these, mustard seed is the most potent.<\/p>\n<p>If you\u2019re not a fan of mature cruciferous vegetables, then consider broccoli sprouts instead. They actually pack a greater punch in terms of nutrition, so you don\u2019t have to eat as much. According to researchers at Johns Hopkins University, a mere 5 grams (0.17 ounces) of broccoli sprouts contain concentrations of the compound glucoraphanin equal to that found in 150 grams (5.2 ounces) of mature broccoli.<sup><span id=\"edn42\" data-hash=\"#ednref42\">42<\/span><\/sup><\/p>\n<p>Sprouts can also contain up to 100 times more enzymes than raw fruits and vegetables, allowing your body to extract more vitamins, minerals, amino acids and essential fats from the foods you eat. You can easily and inexpensively grow broccoli sprouts at home, indoors, and you don\u2019t have to cook them. They are eaten raw, usually as an addition to salad or juice.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Antimicrobial resistance has been on the rise for decades, making easily treatable infections a serious threat again. The breakthrough could lie in these everyday vegetables, which attack the killer cells<\/p>\n","protected":false},"author":1,"featured_media":1596310,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mo_disable_npp":"","fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[],"tags":[],"class_list":["post-1595897","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/1595897","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/comments?post=1595897"}],"version-history":[{"count":0,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/1595897\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media\/1596310"}],"wp:attachment":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media?parent=1595897"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/categories?post=1595897"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/tags?post=1595897"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}