{"id":1511166,"date":"2022-06-11T20:54:50","date_gmt":"2022-06-12T00:54:50","guid":{"rendered":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=1511166"},"modified":"2022-06-11T20:55:13","modified_gmt":"2022-06-12T00:55:13","slug":"five-keys-to-longevity-and-health-extension-into-old-age","status":"publish","type":"post","link":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/five-keys-to-longevity-and-health-extension-into-old-age\/","title":{"rendered":"Five Keys to Longevity and Health Extension Into Old Age"},"content":{"rendered":"<aside class=\"mashsb-container mashsb-main mashsb-stretched\"><div class=\"mashsb-box\"><div class=\"mashsb-count mash-medium\" style=\"float:left\"><div class=\"counts mashsbcount\">20<\/div><span class=\"mashsb-sharetext\">SHARES<\/span><\/div><div class=\"mashsb-buttons\"><a class=\"mashicon-facebook mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/www.facebook.com\/sharer.php?u=https%3A%2F%2Fwww.conservativenewsdaily.net%2Fbreaking-news%2Ffive-keys-to-longevity-and-health-extension-into-old-age%2F\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Facebook<\/span><\/a><a class=\"mashicon-twitter mash-medium mash-nomargin mashsb-noshadow\" href=\"https:\/\/twitter.com\/intent\/tweet?text=&amp;url=https:\/\/www.conservativenewsdaily.net\/breaking-news\/?p=1511166&amp;via=ConservNewsDly\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Twitter<\/span><\/a><a class=\"mashicon-subscribe mash-medium mash-nomargin mashsb-noshadow\" href=\"#\" target=\"_top\" rel=\"nofollow\"><span class=\"icon\"><\/span><span class=\"text\">Subscribe<\/span><\/a><div class=\"onoffswitch2 mash-medium mashsb-noshadow\" style=\"display:none\"><\/div><\/div>\n            <\/div>\n                <div style=\"clear:both\"><\/div><\/aside>\n            <!-- Share buttons by mashshare.net - Version: 4.0.47--><h3>Longevity is About More Than Life Span<\/h3>\n<p>When we talk about longevity and life extension, we assume that people want to live a long time, but many have no interest in facing the indignities of old age. That&#8217;s why &#8220;life extension&#8221; is a crappy term. What we should be talking about instead is health extension.<\/p>\n<p>Health extension combines longevity with youthful energy levels and a body free from discomfort. In other words, a future where you change very little and get to keep on doing the same stuff you&#8217;re doing now, only with some wrinkles.<\/p>\n<p>But measuring actual health is somewhat difficult, especially in lab animals. They could be plagued with many of the infirmities of old age but still live a long time. A mouse, for instance, can&#8217;t tell you if its back is hurting or if it&#8217;s having problems in the sack. Measuring life span instead is much easier.<\/p>\n<p>Luckily for us, animals share many biological pathways with humans. That means animal longevity studies correlate pretty well with us Homo sapiens types. Here&#8217;s what these studies revealed to be the major factors that influence life span.<\/p>\n<div class=\"so-accordion-wrapper\">\n<div class=\"so-tab\"><input id=\"so-tab-2\" type=\"checkbox\" name=\"tabs\" \/> <label for=\"so-tab-2\"><\/p>\n<h3>The 3 Champion Phytochemicals<\/h3>\n<p><\/label><\/p>\n<div class=\"so-tab-content\">\n<p>In studies of life-extending phytochemicals, the lab animal of choice is Caenorhabditis elegans \u2013 a nematode that conveniently lives only 20 to 25 days. As implied earlier, you shouldn&#8217;t dis the validity of nematodes as a model of life span because their biochemical processes aren&#8217;t that much different from ours, and what works for them might easily work for us.<\/p>\n<p>With that in mind, these are the compounds that had the greatest effect on their life span.<\/p>\n<h4>1 Pomegranate \u2013 Increased mean life span by 56%<\/h4>\n<figure>\n<a href=\"https:\/\/biotest.t-nation.com\/products\/p-well\"><\/a><br \/><\/figure>\n<p>Much of the &#8220;magic&#8221; associated with pomegranate extract, flesh, and juice comes from punicalagin, large molecules that belong to a class of polyphenols known as ellagitannins, which, once ingested, act in multiple ways.<\/p>\n<p>Some act directly as antioxidants, while others are metabolized by microflora in the gut to form other powerful compounds such as ellagic acid and urolithins.<\/p>\n<p>What&#8217;s hugely compelling about them is that many in-vitro, animal, and human studies have suggested they might play a big role in suppressing prostate tumor growth and metastasis, along with reducing benign prostate hypertrophy (BPH) in general.<\/p>\n<p>More germane to life extension, though, pomegranate\/punicalagin seem to help mitochondria &#8220;house clean,&#8221; a process known as autophagy. In simple terms, it just means ridding the cell of damaged components of the cell, which, done efficiently enough on a body-wide scale, corresponds to a longer life\/health span.<\/p>\n<p>If you&#8217;re already taking Biotest&#8217;s <a href=\"https:\/\/biotest.t-nation.com\/products\/p-well\">P-Well<\/a>\u2122, you&#8217;re getting a potent dose of punicalagin.<\/p>\n<h4>2 Curcumin \u2013 Increased mean life span by 55%<\/h4>\n<figure>\n<a href=\"https:\/\/biotest.t-nation.com\/products\/curcumin\"><img decoding=\"async\" width=\"100%\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/06\/Micellar-Curcumin-2.jpg\" alt=\"Micellar Curcumin\" \/><\/a><br \/><\/figure>\n<p><a href=\"https:\/\/www.t-nation.com\/supplements\/curcumin-benefits-supplement\/\">Curcumin<\/a> continues to impress. It&#8217;s been proven to increase insulin sensitivity, improve sexual health, enhance cardiovascular health, relieve post-exercise soreness, lessen the pain of injured joints, and even attack viruses, among a long list of other things.<\/p>\n<p>It was initially just thought to be a powerful antioxidant, but that trait alone couldn&#8217;t explain how it seems to improve so many aspects of physiology.<\/p>\n<p>Clearly, there&#8217;s something more going on with curcumin, and it&#8217;s now thought to actually mitigate the expression of various age-associated genes. Historically, though, it&#8217;s been plagued by poor absorption, at least in humans. Biotest solved that problem by employing Longvida Optimized Curcumin\u00ae in its <a href=\"https:\/\/biotest.t-nation.com\/products\/curcumin\">Micellar Curcumin<\/a>\u2122 supplement.<\/p>\n<p>Micellar Curcumin increases blood concentrations of curcumin 95 times more than native curcumin. It has an extraordinarily long half-life, presumably making it an even more potent life\/health extender than it ordinarily is.<\/p>\n<h4>3 Rosmarinic Acid \u2013 Increased mean life span by 63%<\/h4>\n<figure>\n<a href=\"https:\/\/amzn.to\/3xKenga\"><img decoding=\"async\" width=\"100%\" src=\"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-content\/uploads\/2022\/06\/Rosmarinic-Acid-1.jpg\" alt=\"Rosmarinic Acid\" \/><\/a><br \/><\/figure>\n<p>Rosmarinic acid is a polyphenol found in, you guessed it, rosemary, but it&#8217;s also found in related spices like basil and sage.<\/p>\n<p>Like almost all the polyphenols (and carotenoids), rosmarinic acid has powerful anti-oxidant and anti-inflammatory properties, but that can&#8217;t explain its wide-ranging effect on various physiological processes.<\/p>\n<p>As with other life\/health-extending phytochemicals, rosmarinic acid seems to up-regulate the expression of certain genes that ultimately affect life span.<\/p>\n<p>Although you can buy rosmarinic acid as a supplement, I chose an alternate route. I get my rosmarinic acid fix through <a href=\"https:\/\/amzn.to\/3xKenga\">Bragg Organic Sprinkle<\/a>. It&#8217;s a seasoning comprised of 24 different organic seeds, leaves, rinds, and spices, of which rosemary is the lead ingredient.<\/p>\n<p>I don&#8217;t know if I&#8217;m getting the most efficacious dosage of rosmarinic acid by just using rosemary instead of a purified rosemary extract. Still, I might be close to the money because I use this spice on all my hot meals. Of course, you can always go the supplement route or even the rosemary tea route.<\/p>\n<\/div>\n<\/div>\n<div class=\"so-tab\"><input id=\"so-tab-3\" type=\"checkbox\" name=\"tabs\" \/> <label for=\"so-tab-3\"><\/p>\n<h3>Fool the Body Into Thinking You&#8217;re Restricting Calories<\/h3>\n<p><\/label><\/p>\n<div class=\"so-tab-content\">\n<p>In a more general sense, many of these life\/health-extending polyphenols and carotenoids mimic calorie restriction, which is the most sure-fire way to extend life (but also the least desirable to humans, particularly athletes).<\/p>\n<p>This calorie-restriction mimicry induces, after a long chain of reactions, the production of antioxidant enzymes like superoxide dismutase (SOD) and catalase (CAT), as well as proteins related to the aforementioned autophagy, a process crucial to maintaining normal cell function.<\/p>\n<p>These phytochemicals also inhibit mTOR, the mammalian target of rapamycin. While having elevated levels of mTOR after a workout helps put on muscle, chronically elevated mTOR levels put the kibosh on the above-mentioned autophagy, in addition to inhibiting SIRT 1, a molecule that, when present in sufficient amounts, increases insulin sensitivity.<\/p>\n<p>So acute, well-timed releases of mTOR good, chronically elevated mTOR bad.<\/p>\n<\/div>\n<\/div>\n<div class=\"so-tab\"><input id=\"so-tab-4\" type=\"checkbox\" name=\"tabs\" \/> <label for=\"so-tab-4\"><\/p>\n<h3>The Runner&#8217;s Up<\/h3>\n<p><\/label><\/p>\n<div class=\"so-tab-content\">\n<p>Many other substances and phytochemicals extend the life of roundworms. Here are the ones that filled out the rest of the field:<\/p>\n<ul>\n<li>Laricitrin \u2013 Increased mean life span by 55%<\/li>\n<li>Myricetin trimethyl ether \u2013 Increased mean life span by 54%<\/li>\n<li>Myricetin \u2013 Increased mean life span by 48%<\/li>\n<li>Baicalein \u2013 Increased mean life span by 45%<\/li>\n<li>Blueberry \u2013 Increased mean life span by 44%<\/li>\n<li>Metformin \u2013 Increased mean life span by 40%<\/li>\n<li>Apple \u2013 Increased mean life span by 39%<\/li>\n<li>Caffeine \u2013 Increased mean life span by 37%<\/li>\n<li>Betula utilis \u2013 Increased mean life span by 36%<\/li>\n<li>Syringetin \u2013 Increased mean life span by 36%<\/li>\n<li>Betalain \u2013 Increased mean life span by 34%<\/li>\n<li>Resperine \u2013 Increased mean life span by 31%<\/li>\n<li>Icariside II \u2013 Increased mean life span by 31%<\/li>\n<li>Polydatin \u2013 Increased mean life span by 31%<\/li>\n<li>Trehalose \u2013 Increased mean life span by 30%<\/li>\n<li>Glucosamine \u2013 Increased mean life span by 30%<\/li>\n<\/ul>\n<p>How much and which specific ones to ingest every day would require a supercomputer to figure out. It just isn&#8217;t feasible.<\/p>\n<p>My advice is to incorporate the top three winners into your diet and attempt to ingest as many of the others regularly by eating a diverse diet. Or at least do the next best thing and supplement with <a href=\"https:\/\/biotest.t-nation.com\/products\/superfood\">Superfood<\/a>, a freeze-dried array of 18 high polyphenol and carotenoid fruits and vegetables.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p>T Nation earns from qualifying purchases as an Amazon Associate. <a href=\"https:\/\/www.t-nation.com\/affiliate-link-policy\/\">Read more<\/a> about our policy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Longevity is About More Than Life Span When we talk about longevity and life extension, we assume that people want to live a long time, but many have no<\/p>\n","protected":false},"author":1,"featured_media":1511243,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mo_disable_npp":"","fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[],"tags":[],"class_list":["post-1511166","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/1511166","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/comments?post=1511166"}],"version-history":[{"count":0,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/posts\/1511166\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media\/1511243"}],"wp:attachment":[{"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/media?parent=1511166"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/categories?post=1511166"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.conservativenewsdaily.net\/breaking-news\/wp-json\/wp\/v2\/tags?post=1511166"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}